L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Shown to preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ).
Chen et al (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68 3169.
Soluble in DMSO (100 mM).
Store at -20° C
n20D ~1.73 (Predicted)
DNA ligase I: IC50 = 5 µM; DNA ligase III : IC50 = 9 µM; DNA ligase IV : IC50 = 5 µM