Molecular structure of L-γ-Carboxyglutamic acid, CAS Number: 53861-57-7
L-γ-Carboxyglutamic acid (CAS 53861-57-7)
Alternate Names:
H-GLA-OH
Application:
L-γ-Carboxyglutamic acid is a metabotropic glutamate receptor subtype ligand
CAS Number:
53861-57-7
Molecular Weight:
191.14
Molecular Formula:
C6H9NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-γ-Carboxyglutamic acid is a mGLuR (metabotropic glutamate receptor) subtype ligand that acts as a group II mGlu-2 receptor, an inhibitor of group III mGlu-7 and group III mGlu-8, and an activator of group III mGlu-4 and group III mGlu-6.
L-γ-Carboxyglutamic acid (CAS 53861-57-7) References
- Undercarboxylation of recombinant prothrombin revealed by analysis of gamma-carboxyglutamic acid using capillary electrophoresis and laser-induced fluorescence. | Vo, HC., et al. 1999. FEBS Lett. 445: 256-60. PMID: 10094467
- Enhanced gamma-carboxylation of recombinant factor X using a chimeric construct containing the prothrombin propeptide. | Camire, RM., et al. 2000. Biochemistry. 39: 14322-9. PMID: 11087381
- Design and concise synthesis of fully protected analogues of l-gamma-carboxyglutamic acid. | Jiang, S., et al. 2006. J Org Chem. 71: 7307-14. PMID: 16958524
- Enhanced stereoselectivity of a Cu(II) complex chiral auxiliary in the synthesis of Fmoc-L-γ-carboxyglutamic acid. | Smith, DJ., et al. 2011. J Org Chem. 76: 1513-20. PMID: 21291260
- Access to α,γ-Diamino Diacid Derivatives via Organocatalytic Asymmetric 1,4-Addition of Azlactones and Dehydroalanines. | Yang, J., et al. 2018. Org Lett. 20: 7080-7084. PMID: 30398880
- Novel synthesis of optically active gamma-carboxyglutamic acid and its derivatives. | Zee-Cheng, RK. and Olson, RE. 1980. Biochem Biophys Res Commun. 94: 1128-32. PMID: 7396954
Inhibitor of:
mGluR-7, and mGLuR-8.Activator of:
mGluR-4, and mGluR-6.Substrate of:
mGluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-γ-Carboxyglutamic acid, 10 mg | sc-295277 | 10 mg | $402.00 | |||
L-γ-Carboxyglutamic acid, 50 mg | sc-295277A | 50 mg | $1047.00 |