Molecular structure of L-701,252, CAS Number: 151057-13-5
L-701,252 (CAS 151057-13-5)
CAS Number:
151057-13-5
Molecular Weight:
263.7
Molecular Formula:
C13H10ClNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-701,252 is a NMDA receptor antagonist acting at the glycine site with an IC50 value of 420 nM.
L-701,252 (CAS 151057-13-5) References
- Evaluation of glycine site antagonists of the NMDA receptor in global cerebral ischaemia. | Hicks, CA., et al. 1999. Brain Res. 819: 65-74. PMID: 10082862
- Emerging therapies in the pharmacological treatment of Parkinson's disease. | Korczyn, AD. and Nussbaum, M. 2002. Drugs. 62: 775-86. PMID: 11929331
- Potential novel targets for Alzheimer pharmacotherapy: I. Secretases. | Maiorini, AF., et al. 2002. J Clin Pharm Ther. 27: 169-83. PMID: 12081630
- NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment. | North, WG., et al. 2010. Clin Pharmacol. 2: 31-40. PMID: 22291485
- NMDA receptors on the surface of cancer cells: target for chemotherapy? | Deutsch, SI., et al. 2014. Biomed Pharmacother. 68: 493-6. PMID: 24751001
- Breast Cancer Subtypes Based on Hypoxia-Related Gene Sets Identify Potential Therapeutic Agents. | Xiong, Z., et al. 2022. Front Mol Biosci. 9: 900005. PMID: 35847977
- 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex. | Rowley, M., et al. 1993. J Med Chem. 36: 3386-96. PMID: 8230129
- Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. | Widdowson, PS., et al. 1996. Brain Res. 738: 236-42. PMID: 8955518
- Characterisation of the binding of [3H]MDL 105,519, a radiolabelled antagonist for the N-methyl-D-aspartate-associated glycine site, to pig cortical brain membranes. | Höfner, G. and Wanner, KT. 1997. Neurosci Lett. 226: 79-82. PMID: 9159494
- N-methyl-D-aspartate (NMDA) receptor antagonists as potential therapeutic agents in neurodegenerative diseases. | Bharadwaj, R., and K. C. Mishra. (2003): Indian journal of pharmacology. 35.5: 326-327.
Inhibitor of:
NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-701,252, 10 mg | sc-205726 | 10 mg | $167.00 | |||
L-701,252, 50 mg | sc-205726A | 50 mg | $800.00 |