L-655,240 (CAS 103253-15-2)
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L-655,240 is primarily utilized in immunological research due to its role as a selective antagonist of the platelet-activating factor receptor. This makes it an important tool for studying inflammatory processes and the modulation of immune responses. Research involving L-655,240 often focuses on its ability to inhibit the actions of platelet-activating factor (PAF), a potent phospholipid activator and mediator of leukocyte function, platelet aggregation, and vascular permeability. L-655,240 is used in experiments designed to understand the role of PAF in allergic reactions, sepsis, and other inflammatory conditions. Additionally, it aids in the investigation of PAF′s involvement in the mechanisms of asthma and anaphylaxis, providing insights into potential intervention points for these conditions.
L-655,240 (CAS 103253-15-2) References
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- Inhibition of platelet-activating factor induced renal hemodynamic and tubular dysfunctions with L-655,240, a new thromboxane-prostaglandin endoperoxide antagonist. | Hébert, RL., et al. 1989. Can J Physiol Pharmacol. 67: 304-8. PMID: 2758373
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- PAF increases vascular permeability in selected tissues: effect of BN-52021 and L-655,240. | Sirois, MG., et al. 1988. Prostaglandins. 36: 631-44. PMID: 3238010
- Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpro pan oic acid); a potent, selective thromboxane/prostaglandin endoperoxide antagonist. | Hall, RA., et al. 1987. Eur J Pharmacol. 135: 193-201. PMID: 3582493
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-655,240, 1 mg | sc-201350 | 1 mg | $57.00 | |||
L-655,240, 5 mg | sc-201350A | 5 mg | $229.00 |