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KV1.3 Antibody (G-9) - Western Blotting - Image 386837
KV1. 3 抗体 (G-9): sc-398855. Western 印迹分析 Jurkat 全细胞裂解液中 KV1. 3 的表达.
KV1.3 Antibody (G-9) - Western Blotting - Image 386837
KV1. 3 抗体 (G-9): sc-398855. Western 印迹分析 Jurkat 全细胞裂解液中 KV1. 3 的表达.
KV1.3 Antibody (G-9) - Western Blotting - Image 309537
KV1. 3 抗体 (G-9): sc-398855. 未转染 293T: sc-117752 (A), 转染人 KV1. 3 的 293T: sc-159570 (B) 和 Jurkat (C) 全细胞裂解液中 KV1. 3 表达的 Western 印迹分析.
KV1. 3 抗体 (G-9): sc-398855. Western 印迹分析 Jurkat 全细胞裂解液中 KV1. 3 的表达.

KV1.3 抗体 (G-9): sc-398855

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寫評論提問

说明书
  • KV1.3 抗体 G-9 是小鼠单克隆 IgG3，KV1.3抗体, 在2篇文献中引用，规格为200 µg/ml
  • 特异性表位图谱分析在human的KV1.3的C-terminal细胞质域内的535-556氨基酸之间进行
  • 推荐用于 mouse, rat 和 human 来源的KV1.3 WB, IP, IF 和 ELISA检测
  • 关于如何获取KV1.3 (G-9): sc-398855的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP是KV1.3 Antibody (G-9) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与KV1.3 Antibody (G-9) 搭配使用（请参阅下面的订购信息）。

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此外 KV 抗体包括 和

KV1.3抗体（G-9）是一种IgG3小鼠单克隆KV1.3抗体（也称为KV1.3抗体），它通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的KV1.3蛋白。KV1.3抗体（G-9）以非偶联抗KV1.3抗体的形式提供。细胞膜上的电压门控K+通道控制着神经元、肌肉和其他可兴奋细胞的动作电位的复极化和频率。KV基因家族编码30多个基因，这些基因构成K+通道的亚基，它们在门控和渗透特性、亚细胞分布和表达模式上有所不同。功能性的KV通道组装成四聚体，由形成孔道的α亚基（KVα）组成，包括KV1、KV2、KV3和KV4蛋白，以及修饰共表达的KVα亚基门控特性的辅助或KVβ亚基。大鼠和人类大脑中表达的主要KV1亚基（KV1.1、KV1.2、KV1.4、KV1.5和KV1.6）在转运、生物合成加工和表面表达模式上存在差异，这表明单个蛋白质亚基受到高度调控，以控制功能性神经元通道的组装和形成。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

KV1.3 抗体 (G-9) 参考文献:

  1. 人类中枢神经系统 Kv1 通道的亚基组成  |  Coleman, SK., et al. 1999. J Neurochem. 73: 849-58. PMID: 10428084
  2. 亚基组成决定了 Kv1 钾通道的表面表达。  |  Manganas, LN. and Trimmer, JS. 2000. J Biol Chem. 275: 29685-93. PMID: 10896669
  3. Kv1.3通道促进心脏代谢与血流之间的联系。  |  Ohanyan, V., et al. 2017. Microcirculation. 24: PMID: 28504408
  4. Kv1.3调节帕金森氏症中的神经炎症和神经变性。  |  Sarkar, S., et al. 2020. J Clin Invest. 130: 4195-4212. PMID: 32597830
  5. 通过遗传和药理学调节评估Kv1.3 K+通道生理学。  |  Varanita, T., et al. 2023. Physiology (Bethesda). 38: 0. PMID: 35998249
  6. 阻断 Kv1.3 钾通道可抑制癫痫中由小胶质细胞介导的神经炎症。  |  Zhang, X., et al. 2022. Int J Mol Sci. 23: PMID: 36499018
  7. Kv1.3在治疗免疫疾病中的焦点。  |  Navarro-Pérez, M., et al. 2024. Expert Opin Ther Targets. 28: 67-82. PMID: 38316438
  8. KCNE4依赖性Kv1.3药理学调节。  |  Sastre, D., et al. 2024. Biochem Pharmacol. 226: 116368. PMID: 38880360
  9. 脑 Kv1.1 钾通道：亚基组装和翻译后加工的体外和体内研究。  |  Deal, KK., et al. 1994. J Neurosci. 14: 1666-76. PMID: 8126562
  10. Kv1 通道亚基五个成员的免疫组化定位：大鼠大脑中不同的亚细胞位置和神经元特异性共定位。  |  Veh, RW., et al. 1995. Eur J Neurosci. 7: 2189-205. PMID: 8563969
  11. Beta 亚基通过生物合成早期的效应促进 K+ 通道表面的表达。  |  Shi, G., et al. 1996. Neuron. 16: 843-52. PMID: 8608002
  12. 哺乳动物脑 K+ 通道复合物中 Kvbeta1 和 Kvbeta2 β-亚基与 Kv1 α-亚基的缔合作用和共定位。  |  Rhodes, KJ., et al. 1997. J Neurosci. 17: 8246-58. PMID: 9334400

订购信息

产品名称产品编号规格价格数量收藏夹

KV1.3 抗体 (G-9)

sc-398855
200 µg/ml
$316.00

KV1.3 (G-9): m-IgG Fc BP-HRP 套装

sc-526332
200 µg Ab; 10 µg BP
$354.00

KV1.3 (G-9) 中和勝肽

sc-398855 P
100 µg/0.5 ml
$68.00

Thank you for your answer, but I see that you also have the two bands that I see in my WB. In your second reference image, you analyzed tree samples, A) HEK293 not transfected, B) HEK293T transfected with Kv1.3 (see two bands here) and C) Jurkat.

Asked by: Salvador72
Thanks for your question! Yes, you can sometimes see additional banding in transfected lysate tests due to incomplete products of translation. These are different than endogenous protein bands. Please reach out directly to your local distributor for further technical assistance if you wish to discuss your results.
Answered by: Tech Service
Date published: 2019-10-23

Hi, I used a free sample of Kv1.3 antibody (G-9). I does a assay diferent T cells models, but in each of these, two nearby bands appear. I would say that they would be approximately 55 and 60 KDa, do you know what these two bands could be due to?

Asked by: Salvador72
Thank you for your question. Unfortunately we do not have any information regarding the bands you are seeing as we have not seen them in house. I would suggest running a secondary control and optimize your conditions to see if you still see these extra bands.
Answered by: Tech Service
Date published: 2019-10-22

What application is the blocking peptide sc-398855 P appropriate for?

Asked by: cjMara
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Another good antibody recognizing a Kv memberThe kv1.3 antibody is an excellent antibody that I tested for western blot. Usually membrane proteins are tricky, they shift a lot in mass because of different post transnational modifications in tissue samples, The KCNA3/Kv1.3 gives a protein of 63kDa in human (theoretical, calculated by Expassy), in rat and mouse, the genomic regions harboring Kv1.3 is still not resolved and therefore, no transcripts yet, but it should be around the same mol weight as of human. In the blot picture (attached) you can clearly see a approximately 75kDa protein band which is Kv1.3 and then there is a higher molecular weight approximately 180 kDa band that is possibly the glycosylated form. It is interesting this the Kv1.3 band is less intense for another brain tissue (right panel) but the non-specific band is of comparable intensity (indicating same amount of proteins loaded for 2 tissues) suggesting that this gene is deferentially expressed in different parts of the rat brain. Also this is an indication of the specificity of the antibody. So, I will definitely recommend this antibody for your research.
Date published: 2017-04-10
Rated 5 out of 5 by from Produced positive Western blot data of KV1Produced positive Western blot data of KV1.3 expression in non-transfected 293T, human KV1.3 transfected 293T and Jurkat whole cell lysates. -SCBT QC
Date published: 2014-05-21
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KV1.3 抗体 (G-9) is rated 5.0 out of 5 by 2.
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