Date published: 2025-9-7
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KIFC1 Antibody (M-63) - Western Blotting - Image 384442
KIFC1 抗体 (M-63): sc-100947. HeLa (A) 和 293T (B) 全细胞裂解液中 KIFC1 表达的 Western 印迹分析.
KIFC1 抗体 (M-63): sc-100947. HeLa (A) 和 293T (B) 全细胞裂解液中 KIFC1 表达的 Western 印迹分析.

KIFC1 抗体 (M-63): sc-100947

4.3(4)
寫評論提問

说明书
  • KIFC1 抗体 M-63 是小鼠单克隆 IgG2a κ，KIFC1抗体, 在14篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组KIFC1
  • 推荐用于 human 来源的KIFC1 WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取KIFC1 (M-63): sc-100947的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 是 KIFC1 抗体 (M-63) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与KIFC1 抗体 (M-63) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外KIF抗体，包括KIF12, KIF13B, KIF14, KIF15, KIF17, KIF18A, KIF1B, KIF20A, KIF21B和KIF26A

KIFC1抗体（M-63）是一种IgG2a κ小鼠单克隆KIFC1抗体，可通过WB、IP、IF、IHC（P）和ELISA检测人源的KIFC1蛋白。KIFC1抗体（M-63）以非偶联的抗KIFC1抗体形式提供。驱动蛋白构成了一个庞大的微管依赖性运动蛋白家族，负责细胞内众多细胞器、囊泡和大分子复合物的分布。单个驱动蛋白成员在细胞分裂、细胞内运输和膜转运事件（包括内吞和转胞吞）中发挥着至关重要的作用。KIFC1（驱动蛋白家族成员C1），也称为HSET或KNSL2（类似驱动蛋白2），是一种由673个氨基酸组成的蛋白质，属于类似驱动蛋白家族。KIFC1定位于细胞核，并含有一个C端驱动蛋白运动结构域。作为一种指向负端的微管依赖性运动蛋白，KIFC1与NuMA和细胞质Dynein一起作用，在纺锤极处组织微管负端。缺乏KIFC1的HeLa细胞表现出多极有丝分裂纺锤体，这表明KIFC1对于双极纺锤体的形成至关重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

KIFC1 抗体 (M-63) 参考文献:

  1. HSET 基因座的基因组组织以及 HLA 相关基因与不动纤毛综合征（ICS）的可能缔合作用。  |  Janitz, K., et al. 1999. Immunogenetics. 49: 644-52. PMID: 10369922
  2. 分子马达及其在膜交通中的作用。  |  Hamm-Alvarez, SF. 1998. Adv Drug Deliv Rev. 29: 229-242. PMID: 10837592
  3. 运动蛋白驱动蛋白的突变体，可在微管上双向运动。  |  Endow, SA. and Higuchi, H. 2000. Nature. 406: 913-6. PMID: 10972296
  4. 小鼠 C 端驱动蛋白马达 KifC3 的分子克隆和功能分析。  |  Yang, Z., et al. 2001. Mol Cell Biol. 21: 765-70. PMID: 11154264
  5. 驱动蛋白-II，异源驱动蛋白。  |  Cole, DG. 1999. Cell Mol Life Sci. 56: 217-26. PMID: 11212349
  6. C 端驱动蛋白马达 KIFC1 参与顶体生物发生和囊泡运输。  |  Yang, WX. and Sperry, AO. 2003. Biol Reprod. 69: 1719-29. PMID: 12826589
  7. 分子马达 KIFC1 与含有核疏松蛋白 NUP62 的复合体缔合作用，该复合体在发育过程中受小 GTP 酶 RAN 的调控。  |  Yang, WX., et al. 2006. Biol Reprod. 74: 684-90. PMID: 16371587
  8. KAR3 运动结构域突变抑制了酿酒酵母驱动蛋白相关 CIN8 和 KIP1 的功能缺失。  |  Hoyt, MA., et al. 1993. Genetics. 135: 35-44. PMID: 8224825
  9. 克隆位于人类 MHC 区域中心粒末端的一个新的驱动蛋白相关基因。  |  Ando, A., et al. 1994. Immunogenetics. 39: 194-200. PMID: 8276466

订购信息

产品名称产品编号规格价格数量收藏夹

KIFC1 抗体 (M-63)

sc-100947
100 µg/ml
$333.00

KIFC1 (M-63): m-IgG Fc BP-HRP 套装

sc-551896
100 µg Ab; 10 µg BP
$354.00

Hello, are you able to tell us where the epitope is in the protein sequence, that the antibody recognises? We are working with a slightly truncated version of KIFC1 and would like to know whether the antibody will recognise this. Many thanks!

Asked by: ZoeG
Thank you for your question. KIFC1 Antibody (M-63): sc-100947 was raised against recombinant KIFC1 of human origin. No epitope mapping has been performed for this antibody up to now.
Answered by: Tech Support Europe
Date published: 2023-06-02

Hello, I am interested in the KIFC1/HSET antibody for WB (Cat# KIFC1 (M-63): sc-100947). Could I get a test sample to try out before I purchase the antibody? Thank you, Vaishali Sridhar

Asked by: Vaishali
Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
Answered by: Technical Support
Date published: 2018-12-19

Can sc-100947: KIFC1 (M-63) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: DefinitelyNotMatt
Thank you for your question. Yes, sc-100947: KIFC1 (M-63) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Good for use in multiple assaysThis antibody has been used for western blotting and immunofluorescence in published research. -SCBT QC
Date published: 2023-09-14
Rated 4 out of 5 by from Working for immunofluorescenceThe antibody is working OK for immunofluorescence.
Date published: 2018-02-15
Rated 4 out of 5 by from Robust immunoperoxidase cytoplasmic stainingRobust immunoperoxidase cytoplasmic staining in formalin-fixed, paraffin-embedded human lymph node tissue. -SCBT QC
Date published: 2015-03-13
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KIFC1 抗体 (M-63) is rated 4.3 out of 5 by 4.
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