K-cadherin Antibody (2B6): sc-59974

K-cadherin Antibody (2B6) is a mouse monoclonal IgG1 antibody that detects K-cadherin protein of mouse, rat, and human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Anti-K-cadherin antibody (2B6) is available as a non-conjugated format. K-cadherin, also known as Cadherin-6, plays a crucial role in cell adhesion, which is essential for maintaining tissue integrity and facilitating proper morphogenesis during development. K-cadherin is primarily located at the cell membrane, where K-cadherin forms adherens junctions that connect adjacent cells, thereby contributing to the structural stability of tissues. K-cadherin at these junctions is vital for processes such as embryonic development and tissue repair, as K-cadherin helps regulate cell signaling pathways and maintain cellular architecture. Additionally, K-cadherin interacts with various cytoplasmic proteins, including β-catenin, which further underscores K-cadherin′s importance in cellular communication and adhesion. Members of the cadherin family, including K-cadherin, are integral to the formation of multicellular structures and play significant roles in both normal physiology and disease states, making anti-K-cadherin antibody (2B6) a valuable tool for researchers studying cell adhesion mechanisms and related biological processes.

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K-cadherin Antibody (2B6) References:

1. Genomic organization and chromosomal mapping of the mouse P-cadherin gene.  |  Hatta, M., et al. 1991. Nucleic Acids Res. 19: 4437-41. PMID: 1886768
2. Distinct roles of cadherin-6 and E-cadherin in tubulogenesis and lumen formation.  |  Jia, L., et al. 2011. Mol Biol Cell. 22: 2031-41. PMID: 21508319
3. Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface.  |  Karthikeyan, S., et al. 2016. Oncotarget. 7: 69871-69882. PMID: 27563818
4. Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.  |  Bialucha, CU., et al. 2017. Cancer Discov. 7: 1030-1045. PMID: 28526733
5. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.  |  Takeichi, M. 1988. Development. 102: 639-55. PMID: 3048970
6. Murine cadherin-6 mediates thrombosis in vivo in a platelet-independent manner.  |  Bouck, EG., et al. 2021. Res Pract Thromb Haemost. 5: 125-131. PMID: 33537536
7. Desmosomal cadherins: another growing multigene family of adhesion molecules.  |  Koch, PJ. and Franke, WW. 1994. Curr Opin Cell Biol. 6: 682-7. PMID: 7833048
8. Cadherins and catenins: interactions and functions in embryonic development.  |  Ranscht, B. 1994. Curr Opin Cell Biol. 6: 740-6. PMID: 7833053
9. Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.  |  Tanihara, H., et al. 1994. Cell Adhes Commun. 2: 15-26. PMID: 7982033
10. Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells.  |  Ayalon, O., et al. 1994. J Cell Biol. 126: 247-58. PMID: 8027182
11. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.  |  Hinck, L., et al. 1994. J Cell Biol. 125: 1327-40. PMID: 8207061
12. Morphogenetic roles of classic cadherins.  |  Takeichi, M. 1995. Curr Opin Cell Biol. 7: 619-27. PMID: 8573335

The preferred K-cadherin antibody is K-cadherin Antibody (4A10): sc-71463.