ITSA1 CAS: 200626-61-5
MF: C13H7Cl2N3O
MW: 292.12
An HDAC activator via TSA suppression.

ITSA1 (CAS 200626-61-5)

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同义词: N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide;1-(2,4-Dichlorobenzoyl)-1H-benzotriazole
应用; An HDAC activator via TSA suppression
CAS号码: 200626-61-5
纯度: 98%
分子量: 292.12
分子式: C13H7Cl2N3O
* 参考分析证明 大量特定数据 (包括水 含量).
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ITSA1 (N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. TSA (Trichostatin A) is an inhibitor of histone deacetylase. ITSA1 was found to specifically counteract TSA-induced cell cycle arrest, histone acetylation, transcriptional activation, and cytoplasmic alpha-tubulin acetylation.


参考文献

1. Haggarty, S.J., et al. 2003. Chem. Biol. 10: 1267-1279. PMID: 14700634
2. Koeller, K.M., et al. 2003. Chem. Biol. 10: 397-410. PMID: 12770822

物理状态 :
Solid
溶解度 :
Soluble in DMSO (25 mg/mL).
保存 :
Store at 4° C
熔点 :
172.79° C
沸点 :
483.41° C at 760 mmHg
密度 :
1.52 g/cm3
折射率 :
n20D 1.71
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
771910
MDL 号码 :
MFCD00195103
SMILES :
C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl

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