Isotetrandrine CAS: 477-57-6
MF: C38H42N2O6
MW: 622.80
A biscoclaurine alkaloid inhibitor of G protein activation of PLA2.

Isotetrandrine (CAS 477-57-6)

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同义词: Berbamine methyl ether
应用; A biscoclaurine alkaloid inhibitor of G protein activation of PLA2
CAS号码: 477-57-6
纯度: 98%
分子量: 622.80
分子式: C38H42N2O6
* 参考分析证明 大量特定数据 (包括水 含量).
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Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2 but not PLC or PLD. It has been suggested that isotetrandrine suppresses the receptor-mediated phospholipase A2 activation by uncoupling a GTP-binding protein from the enzyme. Isotetrandrine has been reported to inhibit collagen, thrombin, and arachidonic acid-induced platelet aggregation. Isotetrandrine has been found to inhibit arachidonic acid liberation of platelets induced by compound 48/80, antigen, GTPβS and Ca2+. Isotetrandrine is an inhibitor of AR (α1 adrenoceptor).


参考文献

1. Hashizume, T., et al. 1991. Biochem. Pharmacol. 41: 419-423. PMID: 1899790
2. Akiba, S., et al. 1992. Biochem. Pharmacol. 44: 45-50. PMID: 1632837

物理状态 :
Solid
溶解度 :
Soluble in ethanol (25 mg/ml), DMSO (20 mg/ml), acetone, and chloroform.
保存 :
Store at -20° C
沸点 :
~710.5° C at 760 mmHg (Predicted)
密度 :
~1.2 g/cm3 (Predicted)
折射率 :
n20D 1.59
IC50 :
Dopamine transporter: IC50 = 4.2 µM (Rattus norvegicus)
pK值 :
pKb: 7.70
仅供科研使用。不可用于诊断或治疗。
RTECS :
NX7285000
PubChem CID :
457825
SMILES :
CN1CCC2=CC(=C3C=C2[[email protected]@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[[email protected]@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC

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