Molecular structure of Isoflupredone Acetate, CAS Number: 338-98-7
Isoflupredone Acetate (CAS 338-98-7)
Alternate Names:
21-Acetoxy-9-fluoro-11?,17-dihydroxypregna-1,4-diene-3,20-dione
Application:
Isoflupredone Acetate is corticosteroid with both glucocorticoid and mineralocorticoid activity
CAS Number:
338-98-7
Molecular Weight:
420.47
Molecular Formula:
C23H29FO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Isoflupredone acetate is a compound of interest in the field of biochemistry and molecular biology for its role in the study of corticosteroid action mechanisms. It is used in research to investigate glucocorticoid receptor interactions and the subsequent gene expression changes in cells. Researchers employ isoflupredone acetate to understand the modulation of cytokine production and the inhibition of inflammatory mediator release. Moreover, it is utilized in the exploration of cell signaling pathways, particularly those involving NF-kB and MAPK, which are key to the regulation of immune responses. Isoflupredone acetate′s structure, with its acetate group, makes it an interesting candidate for studies on the impact of esterification on corticosteroid activity and bioavailability.
Isoflupredone Acetate (CAS 338-98-7) References
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- Comparison of efficacy and tolerability of isoflupredone and dexamethasone in the treatment of horses affected with recurrent airway obstruction ('heaves'). | Picandet, V., et al. 2003. Equine Vet J. 35: 419-24. PMID: 12880012
- Effects of two anti-inflammatory drugs on physiologic variables and milk production in cows with endotoxin-induced mastitis. | Wagner, SA. and Apley, MD. 2004. Am J Vet Res. 65: 64-8. PMID: 14719704
- Effect of endotoxic mastitis on epithelial cell numbers in the milk of dairy cows. | Wagner, SA., et al. 2009. Am J Vet Res. 70: 796-9. PMID: 19496671
- Impact of isoflupredone acetate treatment on clinical signs and weight gain in weanling heifers with experimentally induced Mannheimia haemolytica bronchopneumonia. | Hewson, J., et al. 2011. Am J Vet Res. 72: 1613-21. PMID: 22126689
- Disposition of isoflupredone acetate in plasma, urine and synovial fluid following intra-articular administration to exercised Thoroughbred horses. | Knych, HK., et al. 2016. Drug Test Anal. 8: 141-7. PMID: 26333097
- Quantification of bupivacaine hydrochloride and isoflupredone acetate residues in porcine muscle, beef, milk, egg, shrimp, flatfish, and eel using a simplified extraction method coupled with liquid chromatography-triple quadrupole tandem mass spectrometry. | Cho, SH., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1065-1066: 29-34. PMID: 28946122
- Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. | Knych, HK., et al. 2018. Equine Vet J. 50: 504-512. PMID: 29044706
- In vitro effects of three equimolar concentrations of methylprednisolone acetate, triamcinolone acetonide, and isoflupredone acetate on equine articular tissue cocultures in an inflammatory environment. | Trahan, RA., et al. 2018. Am J Vet Res. 79: 933-940. PMID: 30153056
- Pharmacokinetics and pharmacodynamics of intra-articular isoflupredone following administration to horses with lipopolysaccharide-induced synovitis. | Knych, HK., et al. 2022. BMC Vet Res. 18: 436. PMID: 36514067
- Effect of isoflupredone acetate on pregnancy in cattle. | Mohammedsadegh, M. 1994. Vet Rec. 134: 453. PMID: 8048222
- Plasma, urine, and synovial fluid disposition of methylprednisolone acetate and isoflupredone acetate after intra-articular administration in horses. | Lillich, JD., et al. 1996. Am J Vet Res. 57: 187-92. PMID: 8633806
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isoflupredone Acetate, 10 mg | sc-470912 | 10 mg | $200.00 |