IL-1 alpha Antibody (B-7): sc-9983

IL-1α Antibody (B-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects IL-1α of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin embedded sections (IHCP). IL-1α Antibody (B-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-1α is a key pro-inflammatory cytokine that plays a vital role in the immune response and inflammation. IL-1α is primarily produced by activated macrophages and is crucial for mediating the body′s response to infection and injury. IL-1α is predominantly located in the cytoplasm of cells, where IL-1α is synthesized and stored in an inactive form. Upon cellular activation, IL-1α is released into the extracellular space, where IL-1α can bind to the IL-1 receptor and initiate a cascade of inflammatory responses. This localization allows for rapid release and action during immune challenges, making IL-1α a critical player in the regulation of immune responses, including the activation of T and B lymphocytes and natural killer cells. Dysregulation of IL-1α has been implicated in various pathological conditions, such as rheumatoid arthritis and inflammatory bowel disease, highlighting IL-1α′s importance in both health and disease.

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IL-1 alpha Antibody (B-7) References:

1. The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.  |  Tapia, VS., et al. 2019. J Biol Chem. 294: 8325-8335. PMID: 30940725
2. Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes.  |  Tsuchiya, K., et al. 2021. Cell Rep. 34: 108887. PMID: 33761363
3. β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles.  |  Ratitong, B., et al. 2021. Cell Rep. 35: 109139. PMID: 34010648
4. IL-1α and colorectal cancer pathogenesis: Enthralling candidate for anti-cancer therapy.  |  Cheng, KJ., et al. 2021. Crit Rev Oncol Hematol. 163: 103398. PMID: 34147647
5. Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection.  |  Eislmayr, K., et al. 2022. Sci Adv. 8: eabj7293. PMID: 35235356
6. Associations between IL-1α, IL-1β, TNFα, and IL-6 variations, and susceptibility to transposition of the great arteries.  |  Atasoy Karakas, L., et al. 2022. BMC Cardiovasc Disord. 22: 229. PMID: 35590253
7. Increased IL-1α expression in chronic rhinosinusitis with nasal polyps.  |  Cao, Y., et al. 2023. Eur Arch Otorhinolaryngol. 280: 1209-1217. PMID: 36168003
8. The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury.  |  Sato, K., et al. 2023. Glia. 71: 2609-2622. PMID: 37470163
9. IL-1α facilitates GSH synthesis to counteract oxidative stress in oral squamous cell carcinoma under glucose-deprivation.  |  Ji, Y., et al. 2024. Cancer Lett. 589: 216833. PMID: 38548217
10. Processing of angiocrine alarmin IL-1α in endothelial cells promotes lung and liver fibrosis.  |  Zhang, C., et al. 2024. Int Immunopharmacol. 134: 112176. PMID: 38723369

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-1α Antibody (B-7) has 31 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-1α Antibody (B-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-1α Antibody (B-7) Specifications

Alternate Product Name: IL-1α

Product Clone Name: B-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 113-271

Epitope Target: IL-1α

Epitope Species: human

Product Reactivity/Detection: IL-1α

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for IL-1α Antibody (B-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred IL-1α antibody is IL-1α Antibody (G-10): sc-271618.