Date published: 2025-9-7

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IL-13Rα1 抗体 (D-2): sc-398831

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说明书
  • IL-13R alpha 1 抗体 D-2 是小鼠单克隆 IgG1 κ,IL-13Rα1抗体, 在4篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列128-427位于human物种的IL-13Rα1的C-terminus
  • IL-13R alpha 1 抗体 (D-2) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 IL-13Rα1
  • 抗IL-13R alpha 1抗体(D-2)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取IL-13Rα1 (D-2): sc-398831免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是IL-13Rα1 Antibody (D-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与IL-13Rα1 Antibody (D-2) 打包提供(请参阅下面的订购信息)。

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関連項目

IL-13Rα1抗体(D-2)是一种IgG1 κ小鼠单克隆IL-13R alpha 1抗体(也称为IL-13Rα1抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的IL-13R alpha 1蛋白。IL-13Rα1抗体(D-2)既有非偶联抗IL-13R alpha 1抗体形式,也有多种偶联形式的抗IL-13R alpha 1抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Th2细胞因子白细胞介素-13(IL-13)在过敏原诱导的气道高反应性(AHR)中起关键作用。IL-13存在两种不同的受体,分别命名为IL-13Rα1和2。IL-13Rα1作为信号亚基以IL-13Rα1和IL-4Rα的异二聚体形式存在,而IL-13Rα2则作为IL-13的诱饵受体。此外,TNFα或IL-4刺激可诱导IL-13Rα2上调,而IL-13Rα1则呈组成性表达。IL-13Rα2的细胞表面定位可阻断IL-13信号传导,因此IL-13诱导受体从细胞质中易位为IL-13信号的负反馈提供了一种机制。IL-13Rα1主要在B细胞、单核细胞和T细胞中表达,而IL-13Rα2在胶质瘤细胞中的表达最高。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IL-13Rα1 抗体 (D-2) 参考文献:

  1. 大鼠 IL-13 alpha 2 受体 cDNA 的分子克隆及其在大鼠组织中的表达。  |  Wu, AH. and Low, WC. 2002. J Neurooncol. 59: 99-105. PMID: 12241113
  2. 支气管上皮细胞中 IL-13 受体 alpha2 链对 IL-13 信号的负反馈调节。  |  Yasunaga, S., et al. 2003. Cytokine. 24: 293-303. PMID: 14609571
  3. TNF-α 和 IL-4 可调节人成纤维细胞 IL-13 受体 alpha2 的表达。  |  Yoshikawa, M., et al. 2003. Biochem Biophys Res Commun. 312: 1248-55. PMID: 14652008
  4. 与过敏原诱导的气道高反应性相比,呼吸道合胞病毒诱导的气道高反应性与 IL-13 无关。  |  Park, JW., et al. 2003. J Allergy Clin Immunol. 112: 1078-87. PMID: 14657862
  5. 外周血嗜酸性粒细胞上白细胞介素-13受体α1-亚基的表达受细胞因子调节。  |  Myrtek, D., et al. 2004. Immunology. 112: 597-604. PMID: 15270731
  6. 分析小儿脑肿瘤中白细胞介素-13受体α2的表达。  |  Kawakami, M., et al. 2004. Cancer. 101: 1036-42. PMID: 15329913
  7. 针对IL-4和IL-13受体的癌症疗法。  |  Suzuki, A., et al. 2015. Cytokine. 75: 79-88. PMID: 26088753
  8. 白细胞介素-3通过Tyk2和STAT6稳定肥大细胞中的CD124/IL-4α表面表达。  |  Drube, S., et al. 2023. Immunology. 169: 102-112. PMID: 36440951
  9. 肥大细胞上IL-13Rα1的低表达使其对IL-13不敏感。  |  Salomaa, T., et al. 2023. J Leukoc Biol. 114: 187-194. PMID: 37224625
  10. 通过IL-4Rα的Th2细胞因子信号传导增加嗜酸性粒细胞粘附因子-3的分泌和人类食管平滑肌的张力。  |  Nelson, MR., et al. 2024. Am J Physiol Gastrointest Liver Physiol. 326: G38-G52. PMID: 37933466
  11. 人类白细胞介素-13受体的染色体图谱和表达。  |  Guo, J., et al. 1997. Genomics. 42: 141-5. PMID: 9177784
  12. B 细胞, T 细胞和单核细胞上 IL-13 受体 alpha1 的表达分布及其受 IL-13 和 IL-4 的调控。  |  Graber, P., et al. 1998. Eur J Immunol. 28: 4286-98. PMID: 9862366

订购信息

产品名称产品编号规格价格数量收藏夹

IL-13Rα1 抗体 (D-2)

sc-398831
200 µg/ml
$316.00

IL-13Rα1 (D-2): m-IgG Fc BP-HRP 套装

sc-530942
200 µg Ab; 10 µg BP
$354.00

IL-13Rα1 (D-2): m-IgGκ BP-HRP 套装

sc-524502
200 µg Ab, 40 µg BP
$354.00

IL-13Rα1 (D-2): m-IgG1 BP-HRP 套装

sc-544328
200 µg Ab; 20 µg BP
$354.00

IL-13Rα1 抗体 (D-2) AC

sc-398831 AC
500 µg/ml, 25% agarose
$416.00

IL-13Rα1 抗体 (D-2) HRP

sc-398831 HRP
200 µg/ml
$316.00

IL-13Rα1 抗体 (D-2) FITC

sc-398831 FITC
200 µg/ml
$330.00

IL-13Rα1 抗体 (D-2) PE

sc-398831 PE
200 µg/ml
$343.00

IL-13Rα1 抗体 (D-2) Alexa Fluor® 488

sc-398831 AF488
200 µg/ml
$357.00

IL-13Rα1 抗体 (D-2) Alexa Fluor® 546

sc-398831 AF546
200 µg/ml
$357.00

IL-13Rα1 抗体 (D-2) Alexa Fluor® 594

sc-398831 AF594
200 µg/ml
$357.00

IL-13Rα1 抗体 (D-2) Alexa Fluor® 647

sc-398831 AF647
200 µg/ml
$357.00

IL-13Rα1 抗体 (D-2) Alexa Fluor® 680

sc-398831 AF680
200 µg/ml
$357.00

IL-13Rα1 抗体 (D-2) Alexa Fluor® 790

sc-398831 AF790
200 µg/ml
$357.00

Received the antibody. The instructions say "store at 4 degrees Celsius,DONT FREEZE”,can I Add quantitative glycerol and store at 4-20 degrees Celsius?

Asked by: zgyzgy
Thank you for your question. No, please don't add glycerol. Please store it according to the datasheet, store at 4 degrees Celsius. DO NOT FREEZE.
Answered by: Technical Service SH
Date published: 2022-01-13

Received the antibody. The instructions say "store at 4 degrees Celsius,DONT FREEZE”,can I Add quantitative glycerol and store at -20 degrees Celsius?

Asked by: zgyzgy
Thank you for your question. No, please don't add glycerol. Please store it according to the datasheet, store at 4 degrees Celsius. DO NOT FREEZE.
Answered by: Technical Service SH
Date published: 2022-01-13

Received the antibody. The instructions say "store at 4 degrees Celsius,DONT FREEZE”,can I Add quantitative glycerol and store at 4 degrees Celsius?

Asked by: zgyzgy
Thank you for your question. No, please don't add glycerol. Please store it according to the datasheet, store at 4 degrees Celsius. DO NOT FREEZE.
Answered by: Technical Service SH
Date published: 2022-01-13

I need to use an antibody to detect the protein in samples of avian origin. Do you know if sc-398831: IL-13Rå1 (D-2) mouse monoclonal antibody will work?

Asked by: DefinitelyNotMatt
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06

Hi, I would like to know whether this antibody has been tested for neutralization (of IL-13 signaling). If not, I would kindly ask for a sample to test this myself (and of course I will let you know the results). Best,

Asked by: AlmogBitton
Thank you for your question. We are not aware of any publications citing use of our IL-13Rα1 Antibody (D-2): sc-398831 for neutralization studies, and this is not a research application that we would test the antibody for in-house. Please contact our Technical Service Department to request a free 10 µg sample of this antibody, available for a limited time. Please call our European Support office toll-free at 00800 4573 8000, email europe@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Excelente resultadoMe proporcionaron una muestra de este producto para probarlo y estamos encantados con el resultado
Date published: 2018-01-24
Rated 5 out of 5 by from wonderful antibodya wonderful data published in WB,for this results,we use it in human cell
Date published: 2016-12-05
Rated 5 out of 5 by from Produced positive Western blot data of ILProduced positive Western blot data of IL-13R 1 expression in non-transfected and human IL-13R 1 transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-10-15
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IL-13Rα1 抗体 (D-2) is rated 5.0 out of 5 by 3.
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