IgA1 Antibody (3C10): sc-51991
- IgA1 Antibody (3C10) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against IgA from human colostrum
- recommended for detection of IgA1 of human origin by ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IgA1 Antibody (3C10). This work is in progress.
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SEE ALSO...
IgA1 Antibody (3C10) is a mouse monoclonal IgG1 antibody that detects immunoglobulin A1 in human samples through enzyme-linked immunosorbent assay (ELISA). Immunoglobulin A1 (3C10) antibody recognizes a protein that plays a crucial role as a first line of defense against microbial pathogens, primarily found in mucosal areas such as the respiratory and gastrointestinal tracts, where immunoglobulin A1 helps to neutralize and eliminate invading microorganisms. The structure of immunoglobulin A1 consists of two heavy chains and two light chains, forming a Y-shaped molecule that allows for effective binding to antigens. The flexibility of the Y-shaped structure enhances immunoglobulin A1′s ability to interact with various pathogens, facilitating their neutralization and clearance. The constant regions of immunoglobulin A1 are essential for maintaining structural integrity and stability, as well as for mediating interactions with other immune components. Anti-immunoglobulin A1 antibody (3C10) serves as an invaluable tool for researchers studying immune responses and the role of immunoglobulins in health and disease.
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IgA1 Antibody (3C10) References:
- Binding capacity of in vitro deglycosylated IgA1 to human mesangial cells. | Zhang, JJ., et al. 2006. Clin Immunol. 119: 103-9. PMID: 16442846
- Sites in the CH3 domain of human IgA1 that influence sensitivity to bacterial IgA1 proteases. | Senior, BW. and Woof, JM. 2006. J Immunol. 177: 3913-9. PMID: 16951354
- Separation of human IgA1 and IgA2 using jacalin-agarose chromatography. | Gregory, RL., et al. 1987. J Immunol Methods. 99: 101-6. PMID: 3106500
- Glomerular deposition of galactose-deficient IgA1-containing immune complexes via glomerular endothelial cell injuries. | Makita, Y., et al. 2022. Nephrol Dial Transplant. 37: 1629-1636. PMID: 35746884
- Genetic Variants of the COL4A3, COL4A4, and COL4A5 Genes Contribute to Thinned Glomerular Basement Membrane Lesions in Sporadic IgA Nephropathy Patients. | Yuan, X., et al. 2023. J Am Soc Nephrol. 34: 132-144. PMID: 36130833
- Author Correction: Protein-based profiling of the human IgA1 clonal repertoire revealed shared clones of serum polymeric IgA1 and milk secretory IgA1. | Novak, J., et al. 2023. Cell Mol Immunol. 20: 310. PMID: 36693924
- Diagnostic and prognostic value of galactose-deficient IgA1 in patients with IgA nephropathy: an updated systematic review with meta-analysis. | Zeng, Q., et al. 2023. Front Immunol. 14: 1209394. PMID: 37671165
- RhoA vesicle trafficking-mediated transglutaminase 2 membrane translocation promotes IgA1 mesangial deposition in IgA nephropathy. | Zhong, Z., et al. 2023. JCI Insight. 8: PMID: 37811653
- IgA nephropathy: gut microbiome regulates the production of hypoglycosilated IgA1 via the TLR4 signaling pathway. | Zhu, Y., et al. 2024. Nephrol Dial Transplant. 39: 1624-1641. PMID: 38402460
- Sparsentan ameliorates glomerular hypercellularity and inflammatory-gene networks induced by IgA1-IgG immune complexes in a mouse model of IgA nephropathy. | Reily, C., et al. 2024. Am J Physiol Renal Physiol. 326: F862-F875. PMID: 38511222
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgA1 Antibody (3C10) | sc-51991 | 100 µg/ml | $322.00 |