Idebenone CAS: 58186-27-9
MF: C19H30O5
MW: 338.44
An antioxidant and neuroprotective agent.

Idebenone (CAS 58186-27-9)

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同义词: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
应用; An antioxidant and neuroprotective agent
CAS号码: 58186-27-9
纯度: ≥98%
分子量: 338.44
分子式: C19H30O5
* 参考分析证明 大量特定数据 (包括水 含量).
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Idebenone, a neuroprotective agent, has been shown to act as a free radical scavenger and protect mitochondrial membranes against lipid peroxidation. This compound has also been found to prevent platelet aggregation and recover cholinergic and monoaminergic changes in murine models. Other studies show that Idebenone displays a capacity to increase nerve growth factor production in cultured rat astrocytes. Additionally, this agent has been reported to dose-dependently inhibit enzymatic metabolism of Arachidonic Acid (sc-200770) in astroglial homogenates.


参考文献

1. Zs -Nagy, I. 1990. Arch Gerontol Geriatr. 11: 177-186. PMID: 15374467
2. Civenni, G., et al. 1999. Eur. J. Pharmacol. 370: 161-167. PMID: 10323265
3. Takuma, K., et al. 2000. Eur. J. Pharmacol. 406: 333-339. PMID: 11040339

物理状态 :
Solid
溶解度 :
Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), methanol, and chloroform. Insoluble in water.
保存 :
Store at room temperature
熔点 :
~192.68° C (Predicted)
沸点 :
~497.3° C at 760 mmHg (Predicted)
密度 :
~1.1 g/cm3 (Predicted)
折射率 :
n20D 1.50
IC50 :
Rattus norvegicus: IC50 = 1300 nM (Rattus norvegicus); Brain: IC50 = 31500 nM (Rattus norvegicus)
pK值 :
pKa: 15.19
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
GU5290000
PubChem CID :
3686
默克索引 :
14: 4888
MDL 号码 :
MFCD00274552
Beilstein 注册 :
2001459
SMILES :
CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCCO

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PMID: # 9840428  Hirai, K. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 358: 582-585.

PMID: # 31783691  Cancers (Basel). 11:

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