ICAM-1/CD54 Antibody (2Q710): sc-71292
- ICAM-1/CD54 Antibody (2Q710) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against an ICAM1-positive cell preparation
- recommended for detection of ICAM-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
- See ICAM-1/CD54 (G-5): sc-8439 for ICAM-1/CD54 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for ICAM-1/CD54 Antibody (2Q710) for WB and IHC(P) applications. This reagent is now offered in a bundle with ICAM-1/CD54 Antibody (2Q710) (see ordering information below).
ICAM-1 Antibody (2Q710) is a mouse monoclonal IgG1 kappa light chain antibody raised against an ICAM-1-positive cell preparation, demonstrating reactivity with mouse, rat, and human species. ICAM-1 monoclonal antibody (2Q710) is suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ICAM-1, also known as CD54 or intercellular adhesion molecule-1, is a cell surface glycoprotein belonging to the immunoglobulin superfamily. ICAM-1 plays a crucial role in mediating cell-cell adhesion during immune responses by interacting with specific proteins like leukocyte function-associated antigen-1 (LFA-1, also known as CD11a/CD18) and Mac-1 (CD11b/CD18) integrins on leukocytes. These interactions facilitate leukocyte adhesion and transmigration across the endothelium, essential for immune surveillance and inflammation. ICAM-1 also interacts with fibrinogen and hyaluronan-binding protein 2, influencing cellular signaling pathways and vascular permeability. Understanding these protein-protein interactions is important for research into inflammatory diseases, autoimmune disorders, and cancer metastasis, where altered ICAM-1 expression and function contribute to disease progression. Anti-ICAM-1 antibody (2Q710) provides a valuable tool for studying ICAM-1′s role in physiological and pathological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ICAM-1/CD54 Antibody (2Q710) References:
- ICAM-1 expression by vascular smooth muscle cells is phenotype-dependent. | Rolfe, BE., et al. 2000. Atherosclerosis. 149: 99-110. PMID: 10704620
- ICAM-1 expression in renal disease. | Chow, J., et al. 1992. J Clin Pathol. 45: 880-4. PMID: 1430258
- ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas. | Burim, RV., et al. 2009. Clin Exp Med. 9: 157-63. PMID: 19306055
- Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response. | Dearth, CL., et al. 2013. PLoS One. 8: e58486. PMID: 23505517
- N-glycosylation deficiency reduces ICAM-1 induction and impairs inflammatory response. | He, P., et al. 2014. Glycobiology. 24: 392-8. PMID: 24474243
- HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells. | Tabet, F., et al. 2014. Nat Commun. 5: 3292. PMID: 24576947
- FOXO1 regulates dendritic cell activity through ICAM-1 and CCR7. | Dong, G., et al. 2015. J Immunol. 194: 3745-55. PMID: 25786691
- Unprecedently high targeting specificity toward lung ICAM-1 using 3DNA nanocarriers. | Roki, N., et al. 2019. J Control Release. 305: 41-49. PMID: 31100312
- Increased ICAM-1 expression in aortic disease. | Davis, CA., et al. 1993. J Vasc Surg. 18: 875-80. PMID: 7693986
- ICAM-1 induction in the mouse CNS following irradiation. | Olschowka, JA., et al. 1997. Brain Behav Immun. 11: 273-85. PMID: 9512815
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICAM-1/CD54 Antibody (2Q710) | sc-71292 | 200 µg/ml | $322.00 | |||
ICAM-1/CD54 Antibody (2Q710): m-IgG Fc BP-HRP Bundle | sc-539359 | 200 µg Ab; 10 µg BP | $361.00 |