Date published: 2025-9-9

021-6093-6350

SCBT Portrait Logo
Seach Input

Hrs 抗体 (D-3): sc-271925

5.0(3)
寫評論提問

说明书
  • Hrs抗体(D-3)是小鼠单克隆IgM κ, 在8篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Hrs的内部区域内的氨基酸121-173之间
  • 推荐用于 mouse, rat, human 和 avian 来源的Hrs WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应,包括: 和 canine, bovine and avian
  • 目前,我们还没有完成Hrs 抗体 (D-3)的首选二抗检测试剂的鉴定。这项工作正在进行中。

快捷链接

関連項目

肝细胞生长因子调节的酪氨酸激酶底物(Hrs)是一种锌指蛋白,与STAM相互作用,并响应IL2、CSF2或HGF进行酪氨酸磷酸化。Hrs参与细胞内转运和信号转导,并与早期内体相关。Hrs包含一个磷脂酰肌醇3-磷酸结合域,该域有助于其内体靶向,其中Hrs通过Hrs羧基末端的网格蛋白盒基序与网格蛋白共定位。Hrs对于腹部折叠形态发生至关重要,并与酵母蛋白Vps27p具有结构相似性,后者参与液泡蛋白分选。人类Hrs基因定位于染色体17q25,编码777个氨基酸的蛋白质。在Schwann 细胞中,Hrs与肿瘤抑制蛋白schwannomin在内体中共定位,提示schwannomin在Hrs介导的细胞信号传导中发挥作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Hrs 抗体 (D-3) 参考文献:

  1. 肝细胞生长因子调控的酪氨酸激酶底物(HRS)介导蛋白酶激活受体2和降钙素受体样受体的后内细胞贩运。  |  Hasdemir, B., et al. 2007. J Biol Chem. 282: 29646-57. PMID: 17675298
  2. 中枢神经系统中 hrs 的缺失会导致泛素化蛋白质的积累和神经变性。  |  Tamai, K., et al. 2008. Am J Pathol. 173: 1806-17. PMID: 19008375
  3. 在果蝇的发育过程中,Hrs/Stam复合体是RTK信号传导的正负调控因子。  |  Chanut-Delalande, H., et al. 2010. PLoS One. 5: e10245. PMID: 20422006
  4. Hrs控制着上皮Na+通道在内膜降解和再循环途径之间的分拣。  |  Zhou, R., et al. 2010. J Biol Chem. 285: 30523-30. PMID: 20675381
  5. 在泛素无关的内体分选过程中,Hrs 可识别细胞因子受体中的疏水氨基酸簇。  |  Amano, Y., et al. 2011. J Biol Chem. 286: 15458-72. PMID: 21362618
  6. 肝细胞生长因子调节的酪氨酸激酶底物(Hgs)通过磷酸化小鼠早期胚胎中的SMADS和TAK1参与BMP信号转导。  |  Miura, S. and Mishina, Y. 2011. Dev Dyn. 240: 2474-81. PMID: 21953618
  7. Hrs 依赖性外泌体途径对丙型肝炎病毒分泌的调控。  |  Tamai, K., et al. 2012. Virology. 422: 377-85. PMID: 22138215
  8. Hrs/Vps27在内质体胆固醇运输中的重要作用  |  Du, X., et al. 2012. Cell Rep. 1: 29-35. PMID: 22832105
  9. ESCRT-0蛋白肝细胞生长因子调控酪氨酸激酶底物(Hrs)可独立于信号转导适配分子(STAM)靶向进入内体,与STAM形成的复合物可促进其内体解离。  |  Kojima, K., et al. 2014. J Biol Chem. 289: 33296-310. PMID: 25296754
  10. Hrs 和 STAM 具有协同功能,可在体外结合泛素修饰的货物。  |  Takahashi, H., et al. 2015. Biophys J. 108: 76-84. PMID: 25564854

订购信息

产品名称产品编号规格价格数量收藏夹

Hrs 抗体 (D-3)

sc-271925
200 µg/ml
$316.00

Hrs (D-3) 中和勝肽

sc-271925 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-271925 P appropriate for?

Asked by: Trav11
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
  • y_2025, m_9, d_5, h_6CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_271925, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 151ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from is goodWestrn blot(dilution 1/1000), the band is clear and special
Date published: 2017-09-08
Rated 5 out of 5 by from Fantastic antibodyUsed in IF at 1:50 dilution and worked fine, recommend to everyone.
Date published: 2017-08-16
Rated 5 out of 5 by from Great immunoperoxidase cytoplasmicc stainingGreat immunoperoxidase cytoplasmicc staining in formalin fixed, paraffin-embedded human pancreas tissue. -SCBT QC
Date published: 2015-03-07
  • y_2025, m_9, d_5, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_zh_CN, sid_271925, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 16ms
  • REVIEWS, PRODUCT
Hrs 抗体 (D-3) is rated 5.0 out of 5 by 3.
  • y_2025, m_9, d_5, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_zh_CN, sid_271925, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 102ms
  • REVIEWS, PRODUCT