Date published: 2025-9-7
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Hrs Antibody (C-7) - Western Blotting - Image 355665
Hrs 抗体 (C-7): sc-271455. Western 印迹分析 Hrs 在 HEL 92. 1. 7 (A), CCRF-CEM (B), HeLa (C), NCI-H1299 (D), HUV-EC-C (E) 和 U-251-MG (F) 全细胞裂解液中的表达.
Hrs 抗体 (C-7): sc-271455. Western 印迹分析 Hrs 在 HEL 92. 1. 7 (A), CCRF-CEM (B), HeLa (C), NCI-H1299 (D), HUV-EC-C (E) 和 U-251-MG (F) 全细胞裂解液中的表达.

Hrs 抗体 (C-7): sc-271455

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说明书
  • Hrs 抗体 C-7 是小鼠单克隆 IgG1 κ，Hrs抗体, 在16篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的Hrs的内部区域内的氨基酸121-173之间
  • Hrs 抗体 (C-7) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 Hrs
  • 抗Hrs抗体（C-7）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Hrs (C-7): sc-271455的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是Hrs Antibody (C-7) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Hrs Antibody (C-7) 打包提供（请参阅下面的订购信息）。

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研究信息

関連項目

此外 Hrs 抗体包括

Hrs抗体（C-7）是一种IgG1 κ小鼠单克隆Hrs抗体（也称为肝细胞生长因子调节的酪氨酸激酶底物抗体、蛋白Pp110抗体、人类生长因子调节的酪氨酸激酶底物抗体、ZFYVE8抗体或Vps27抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的Hrs蛋白。Hrs抗体（C-7）既可以是非偶联的抗Hrs抗体形式，也可以是多种偶联形式的抗Hrs抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。肝细胞生长因子调节的酪氨酸激酶底物（Hrs）是一种锌指蛋白，与STAM相互作用，并响应IL2、CSF2或HGF进行酪氨酸磷酸化。Hrs参与细胞内转运和信号转导，并与早期内体相关。Hrs包含一个磷脂酰肌醇3-磷酸结合域，该域有助于其内体靶向，其中Hrs通过Hrs羧基末端的网格蛋白盒基序与网格蛋白共定位。Hrs对于腹部折叠形态发生至关重要，并与酵母蛋白Vps27p具有结构相似性，后者参与液泡蛋白分选。人类Hrs基因定位于染色体17q25，编码777个氨基酸的蛋白质。在Schwann细胞中，Hrs与肿瘤抑制蛋白schwannomin在内体中共定位，提示schwannomin在Hrs介导的细胞信号传导中发挥作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Hrs 抗体 (C-7) 参考文献:

  1. 神经纤维瘤病 2 肿瘤抑制蛋白与肝细胞生长因子调节的酪氨酸激酶底物相互作用。  |  Scoles, DR., et al. 2000. Hum Mol Genet. 9: 1567-74. PMID: 10861283
  2. Hrs 在内核贩运和信号传导中的功能  |  Raiborg, C., et al. 2001. Biochem Soc Trans. 29: 472-5. PMID: 11498011
  3. Hrs 将 clathrin 募集到早期内体。  |  Raiborg, C., et al. 2001. EMBO J. 20: 5008-21. PMID: 11532964
  4. 树突状细胞的外泌体分泌受 ESCRT-0 蛋白 Hrs 的调控。  |  Tamai, K., et al. 2010. Biochem Biophys Res Commun. 399: 384-90. PMID: 20673754
  5. 表皮生长因子受体（EGFR）和表皮生长因子受体（ErbB2）的再循环与 Hrs 酪氨酸磷酸化受损和 AMSH 去泛素化减少有关。  |  Meijer, IM., et al. 2012. Cell Signal. 24: 1981-8. PMID: 22800866
  6. 依赖 Hrs 和 CD63 的竞争机制制造出不同大小的内膜腔内囊泡。  |  Edgar, JR., et al. 2014. Traffic. 15: 197-211. PMID: 24279430
  7. Ubpy 控制着 ESCRT-0 亚基 Hrs 在发育过程中的稳定性。  |  Zhang, J., et al. 2014. Development. 141: 1473-9. PMID: 24574010
  8. HRS-WASH 轴控制着肌动蛋白介导的内体循环和细胞侵袭。  |  MacDonald, E., et al. 2018. J Cell Biol. 217: 2549-2564. PMID: 29891722
  9. Syk和Hrs调控TLR3介导的小鼠星形胶质细胞抗病毒反应  |  Mielcarska, MB., et al. 2019. Oxid Med Cell Longev. 2019: 6927380. PMID: 31089414
  10. ESCRT-0蛋白HRS与人类T细胞白血病病毒2型反义蛋白APH-2相互作用并抑制病毒复制  |  Martini, F., et al. 2019. J Virol. 94: PMID: 31597781
  11. Hrs 与信号转导适配分子 STAM 缔合作用。它对细胞因子诱导的细胞生长有抑制作用。  |  Asao, H., et al. 1997. J Biol Chem. 272: 32785-91. PMID: 9407053
  12. 人类 Hrs，生长因子刺激细胞中的酪氨酸激酶底物：cDNA 克隆和该基因在 17 号染色体上的图谱。  |  Lu, L., et al. 1998. Gene. 213: 125-32. PMID: 9630564

订购信息

产品名称产品编号规格价格数量收藏夹

Hrs 抗体 (C-7)

sc-271455
200 µg/ml
$316.00

Hrs (C-7): m-IgG Fc BP-HRP 套装

sc-529188
200 µg Ab; 10 µg BP
$354.00

Hrs (C-7): m-IgGκ BP-HRP 套装

sc-521948
200 µg Ab, 40 µg BP
$354.00

Hrs (C-7): m-IgG1 BP-HRP 套装

sc-543377
200 µg Ab; 20 µg BP
$354.00

Hrs 抗体 (C-7) AC

sc-271455 AC
500 µg/ml, 25% agarose
$416.00

Hrs 抗体 (C-7) HRP

sc-271455 HRP
200 µg/ml
$316.00

Hrs 抗体 (C-7) FITC

sc-271455 FITC
200 µg/ml
$330.00

Hrs 抗体 (C-7) PE

sc-271455 PE
200 µg/ml
$343.00

Hrs 抗体 (C-7) Alexa Fluor® 488

sc-271455 AF488
200 µg/ml
$357.00

Hrs 抗体 (C-7) Alexa Fluor® 546

sc-271455 AF546
200 µg/ml
$357.00

Hrs 抗体 (C-7) Alexa Fluor® 594

sc-271455 AF594
200 µg/ml
$357.00

Hrs 抗体 (C-7) Alexa Fluor® 647

sc-271455 AF647
200 µg/ml
$357.00

Hrs 抗体 (C-7) Alexa Fluor® 680

sc-271455 AF680
200 µg/ml
$357.00

Hrs 抗体 (C-7) Alexa Fluor® 790

sc-271455 AF790
200 µg/ml
$357.00

Hrs (C-7) 中和勝肽

sc-271455 P
100 µg/0.5 ml
$68.00

is the antibody conjugated to agarose beads covalently? I already bought the product but need more info.

Asked by: Minoo
Thank you for your question. Hrs Antibody (C-7): sc-271455 AC has agarose covalently bound to the antibody via primary amines.
Answered by: Tech Support Europe
Date published: 2024-10-15

What application is the blocking peptide sc-271455 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Anti-Hrs antibody works well for WBAnti-Hrs antibody works well for WB in prostate and colorectal cancer cells
Date published: 2024-05-10
Rated 5 out of 5 by from Postdoc associateWe got the antibody first in a trial size. It works very well for western blots and IHC in mouse tissue. So we further purchase a full size recently.
Date published: 2020-06-12
Rated 5 out of 5 by from This antibody works very wellI bought this antibody few month ago, it works very well for WB. I like it.
Date published: 2019-10-15
Rated 5 out of 5 by from Produced publishable IP dataThis Hrs monoclonal antibody was referenced in the primary literature for the use in IP on rat mast cells.
Date published: 2017-01-27
Rated 4 out of 5 by from Very good antibodyThis is a very nice antibody working well for WB and IF.
Date published: 2016-11-08
Rated 5 out of 5 by from Produced positive Western Blot data of HrsProduced positive Western Blot data of Hrs expression in non-transfected 293, human Hrs transfected 293, K-562 and M1 whole cell lysates. -SCBT QC
Date published: 2015-04-28
Rated 5 out of 5 by from Satisfactory Western Blot data of Hrs expressionSatisfactory Western Blot data of Hrs expression in K-562 and HEL 92. -SCBT QC
Date published: 2013-08-31
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Hrs抗体 (C-7) is rated 4.9 out of 5 by 7.
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