Date published: 2025-9-7
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Histone Deacetylase 11 (HDAC11) Antibody (C-5) - Western Blotting - Image 381921
HDAC11 抗体 (C-5): sc-390737. COLO 205 全细胞裂解液中 HDAC11 表达的 Western 印迹分析.
Histone Deacetylase 11 (HDAC11) Antibody (C-5) - Western Blotting - Image 381921
HDAC11 抗体 (C-5): sc-390737. COLO 205 全细胞裂解液中 HDAC11 表达的 Western 印迹分析.
Histone Deacetylase 11 (HDAC11) Antibody (C-5) - Immunofluorescence - Image 370993
HDAC11 抗体 (C-5): sc-390737. 福尔马林固定的 HeLa 细胞免疫荧光染色, 显示核定位.
Histone Deacetylase 11 (HDAC11) Antibody (C-5) - Western Blotting - Image 289742
HDAC11 抗体 (C-5): sc-390737. Caki-1 全细胞裂解液中 HDAC11 表达的 Western 印迹分析.
HDAC11 抗体 (C-5): sc-390737. COLO 205 全细胞裂解液中 HDAC11 表达的 Western 印迹分析.

Histone Deacetylase 11 (HDAC11) 抗体 (C-5): sc-390737

4.5(6)
寫評論提問

说明书
  • Histone Deacetylase 11 (HDAC11) 抗体 C-5 是小鼠单克隆 IgG1 κ，Histone Deacetylase 11 (HDAC11)抗体, 在17篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列1-300位于human物种的HDAC11的N-terminus
  • Histone Deacetylase 11 (HDAC11) 抗体 (C-5) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 HDAC11
  • 抗Histone Deacetylase 11 (HDAC11)抗体（C-5）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Histone Deacetylase 11 (HDAC11) (C-5): sc-390737的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和m-IgGκ BP-HRP是Histone Deacetylase 11 (HDAC11) Antibody (C-5) 适用于 WB 应用。 的首选辅助检测试剂，这些试剂现与Histone Deacetylase 11 (HDAC11) Antibody (C-5) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外HDAC抗体，包括HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8和HDAC9

HDAC11 抗体 (C-5) 是针对人 HDAC11 蛋白 N 端前 300 个氨基酸开发的小鼠单克隆 IgG1 kappa 轻链抗体，在小鼠、大鼠和人样本中通过免疫印迹 (WB)、免疫沉淀 (IP)、免疫荧光 (IF) 和酶联免疫吸附 (ELISA) 检测显示出强大的反应活性。HDAC11 又称 HD11，是第四类组蛋白去乙酰化酶的唯一成员，通过去除组蛋白上的乙酰基，导致染色质凝聚和转录抑制，从而在基因表达调控中发挥关键作用。这种酶活性对分化、增殖和凋亡等各种细胞过程至关重要，因此 HDAC11 是维持细胞平衡和表观遗传调控的关键角色。与其他 HDAC 类不同，HDAC11 具有独特的结构特征，可赋予特定的调控功能，包括参与代谢途径和免疫反应调节。HDAC11 在肾脏、心脏、大脑、骨骼肌和睾丸等重要组织中的表达水平很高，在这些组织中，HDAC11 会影响特定组织的基因表达和细胞功能。HDAC11 主要定位于细胞核内，与各种转录因子和共抑制因子相互作用，对正常发育和疾病进展所必需的基因表达模式进行微调。抗 HDAC11 抗体 (C-5) 有非共轭型和多种共轭型，包括辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和 Alexa Fluor® 共轭物，为旨在阐明 HDAC11 在健康和疾病中的复杂作用的广泛研究应用提供了多种选择。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) 参考文献:

  1. 人类组蛋白去乙酰化酶家族新成员 HDAC11 的克隆和功能鉴定。  |  Gao, L., et al. 2002. J Biol Chem. 277: 25748-55. PMID: 11948178
  2. 组蛋白去乙酰化酶家族的分子进化：系统发育分析的功能意义。  |  Gregoretti, IV., et al. 2004. J Mol Biol. 338: 17-31. PMID: 15050820
  3. 急性髓性白血病中的组蛋白去乙酰化酶表现出一种独特的表达模式，这种模式在去乙酰化酶抑制剂的作用下会发生选择性变化。  |  Bradbury, CA., et al. 2005. Leukemia. 19: 1751-9. PMID: 16121216
  4. 新型第四类人类组蛋白去乙酰化酶 11 基因的染色体组织和定位。  |  Voelter-Mahlknecht, S., et al. 2005. Int J Mol Med. 16: 589-98. PMID: 16142391
  5. WNT7A和HDAC11作为散发性恶性胰腺内分泌肿瘤候选抑癌基因的突变分析  |  Lindberg, D., et al. 2007. Clin Endocrinol (Oxf). 66: 110-4. PMID: 17201809

订购信息

产品名称产品编号规格价格数量收藏夹

Histone Deacetylase 11 (HDAC11) 抗体 (C-5)

sc-390737
200 µg/ml
$316.00

Histone Deacetylase 11 (HDAC11) (C-5): m-IgG Fc BP-HRP 套装

sc-530244
200 µg Ab; 10 µg BP
$354.00

Histone Deacetylase 11 (HDAC11) (C-5): m-IgGκ BP-HRP 套装

sc-523658
200 µg Ab, 40 µg BP
$354.00

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) AC

sc-390737 AC
500 µg/ml, 25% agarose
$416.00

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) HRP

sc-390737 HRP
200 µg/ml
$316.00

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) FITC

sc-390737 FITC
200 µg/ml
$330.00

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) PE

sc-390737 PE
200 µg/ml
$343.00

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) Alexa Fluor® 488

sc-390737 AF488
200 µg/ml
$357.00

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) Alexa Fluor® 546

sc-390737 AF546
200 µg/ml
$357.00

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) Alexa Fluor® 594

sc-390737 AF594
200 µg/ml
$357.00

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) Alexa Fluor® 647

sc-390737 AF647
200 µg/ml
$357.00

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) Alexa Fluor® 680

sc-390737 AF680
200 µg/ml
$357.00

Histone Deacetylase 11 (HDAC11) 抗体 (C-5) Alexa Fluor® 790

sc-390737 AF790
200 µg/ml
$357.00

Using this antibody in WB(8% agarose gel), which one is the right band, about 37kDa or 50kDa?

Asked by: jm lee
Thank you for your question. The predicted molecular weight for HDAC11 is approximately 39 kDa. However, we would expect the observed molecular weight to be slightly higher than the predicted molecular weight. Unfortunately, we do not have any references to support a molecular weight as high as 50 kDa. We will review the data using this antibody on our website and make updates very shortly to remove any unsupportive data.
Answered by: Technical Support
Date published: 2017-08-30

If using the Li-Cor system, what is the recommended secondary for this antibody?

Asked by: TinTin
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Tech Service
Date published: 2017-01-30
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Rated 5 out of 5 by from among different HDACs HDAC11 worked bestUsing human blood monocyte derived macrophages, 25 ug total cell lysate ran on midi gels, 1:500 dilution in milk, 1:4000 2nd Ab CST anti-mouse we could detect a band at right size short exposure, pico ECL. This was the best among HDAC9-10-11-2 antibodies I tried on the same day.
Date published: 2021-07-19
Rated 4 out of 5 by from Good antibody for WB.Test this antibody by WB using mouse lung cancer cell lysates and it works well although there are non-specific bands.
Date published: 2017-09-12
Rated 4 out of 5 by from a relative good antibody for WBThis antibody generates a clear signal at the predicted position on the western blot (1:500 dilution, 40ug HeLa extract).
Date published: 2017-09-01
Rated 5 out of 5 by from Great HDAC11 monoclonal choice, strong WB bands!Highly specific strong band in Caki-1 whole cell lysate.
Date published: 2017-01-10
Rated 5 out of 5 by from Used this antibody in WBUsed this antibody in WB, worked well, did not see any non specific bands, happy with purchase.
Date published: 2015-08-17
Rated 4 out of 5 by from Good specificity and signal strength by WesternGood specificity and signal strength by Western in Caki-1 whole cell lysate. -SCBT QC
Date published: 2014-11-01
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Histone Deacetylase 11 (HDAC11) 抗体 (C-5) is rated 4.5 out of 5 by 6.
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