hCAP-D2 Antibody (D-3): sc-166878

hCAP-D2 Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects hCAP-D2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). hCAP-D2 is a crucial component of the condensin complex, which plays a vital role in the resolution and segregation of sister chromatids during mitosis, ensuring accurate chromosome assembly and distribution to daughter cells. hCAP-D2 is primarily located in the nucleus, where hCAP-D2 associates with chromatin and is essential for maintaining chromatid structure during cell division. Proper localization of hCAP-D2 is critical, as any disruption can lead to chromosomal instability, which is a hallmark of many cancers. Additionally, hCAP-D2 interacts with histones H1 and H3 through its C-terminus, highlighting hCAP-D2′s role in chromatin remodeling and regulation during mitosis. A deficiency in hCAP-D2 can result in disorganized chromatid axes and misalignment of sister chromatids, ultimately causing delays in anaphase and contributing to genomic instability. Anti-hCAP-D2 antibody (D-3) is an invaluable tool for researchers studying cell division, chromosomal behavior, and the underlying mechanisms of cancer biology.

The preferred hCAP-D2 antibody is hCAP-D2 Antibody (E-6): sc-398950.