GSTO1/2 Antibody (D-8): sc-166039

GSTO1/2 Antibody (D-8) is a mouse monoclonal IgG1 antibody that detects GSTO1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GSTO1, also known as glutathione S-transferase omega 1 or p28, is a 241 amino acid protein that plays a crucial role in cellular detoxification processes by catalyzing the conjugation of glutathione to various organic compounds, forming thioethers that facilitate the metabolism and elimination of xenobiotics and carcinogens. GSTO1 is predominantly localized in the cytoplasm and exists as a homodimer, which is essential for enzymatic functions, including acting as a glutathione-dependent thiol transferase and a dehydroascorbate reductase. GSTO1′s function is underscored by involvement in protecting cells from oxidative stress and potential damage caused by harmful substances. Notably, polymorphisms in the GSTO1 gene have been linked to an increased risk of developing childhood acute lymphoblastic leukemia, Parkinson′s disease, and Alzheimer′s disease, highlighting significance in both health and disease. Additionally, GSTO2, a related protein, shares functional similarities and is expressed in various tissues, further emphasizing the relevance of the GSTO family in biological processes. anti-GSTO1/2 antibody (D-8) is an invaluable tool for researchers studying the roles of these proteins in cellular function and disease mechanisms.

The preferred GSTO1/2 antibody is GSTO1/2 Antibody (H-12): sc-166121.