GSK-3 Inhibitor X (CAS 740841-15-0)
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GSK-3 Inhibitor X is a specialized acetoxime analog of BIO designed to selectively target and inhibit the activity of glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase involved in numerous cellular signaling pathways. This inhibitor operates by binding to the ATP-binding site of GSK-3, effectively blocking its kinase activity. GSK-3 is a critical enzyme in various biological processes, including protein synthesis, cell differentiation, and cell proliferation, making its inhibition a valuable experimental approach in research settings. Additionally, GSK-3 Inhibitor X serves as a crucial tool for researchers aiming to elucidate the role of GSK-3 in the regulation of the Wnt and Hedgehog signaling pathways, which are essential for cell fate determination and embryonic development.
GSK-3 Inhibitor X (CAS 740841-15-0) References
- Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway. | Khan, KA., et al. 2015. Mol Cell Biol. 35: 3029-43. PMID: 26100021
- Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. | Thornton, TM., et al. 2016. Nat Commun. 7: 10553. PMID: 26822034
- High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis. | Lee, SH., et al. 2017. Biochem Pharmacol. 138: 140-149. PMID: 28522407
- SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. | Sarikhani, M., et al. 2018. Elife. 7: PMID: 29504933
- Chelerythrine Chloride Downregulates β-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma. | Heng, WS. and Cheah, SC. 2020. Molecules. 25: PMID: 31935827
- Cytolethal distending toxin-induced release of interleukin-1β by human macrophages is dependent upon activation of glycogen synthase kinase 3β, spleen tyrosine kinase (Syk) and the noncanonical inflammasome. | Shenker, BJ., et al. 2020. Cell Microbiol. 22: e13194. PMID: 32068949
- Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity. | Dankwa, S., et al. 2021. Cell Chem Biol. 28: 1679-1692.e4. PMID: 34216546
- Regulation of Avian Leukosis Virus Subgroup J Replication by Wnt/β-Catenin Signaling Pathway. | Qiao, D., et al. 2021. Viruses. 13: PMID: 34696398
- DNA damage-induced degradation of Cdc25A does not lead to inhibition of Cdk2 activity in mouse embryonic stem cells | Koledova, Z., et al. 2010. Stem Cells. 28(3): 450-461.
- Discovery of TRAF-2 and NCK-interacting kinase (TNIK) inhibitors by ligand-based virtual screening methods | Anna Bujak; Filip Stefaniak; Daria Zdzalik; Paulina Grygielewicz; Barbara Dymek; Marcin Zagozda, et al. 2015. MedChemComm. 6(8): 1564-1572.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-3 Inhibitor X, 5 mg | sc-221689 | 5 mg | $146.00 |