granzyme M Antibody (C-12): sc-393155

granzyme M Antibody (C-12) is a mouse monoclonal IgG2b antibody that detects granzyme M in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Granzyme M, also known as NK cell granular protease or HU-Met-1, is a serine protease that plays a crucial role in the immune response by localizing to the granules of natural killer (NK) cells and cytotoxic T lymphocytes. Granzyme M is essential for inducing target cell death, as anti-granzyme M antibody (C-12) cleaves peptide substrates after specific amino acids, including leucine, norleucine, or methionine. The ability of granzyme M to selectively target and cleave these substrates is vital for the regulation of apoptosis in infected or malignant cells, thereby contributing to the body′s defense mechanisms. Additionally, granzyme M contains a peptidase S1 domain, which is significant for enzymatic activity and interaction with other proteins involved in the immune response. The granzyme family, including granzyme M, is integral to the cytotoxic functions of lymphocytes, making granzyme M monoclonal antibody (C-12) a valuable tool for researchers studying immune responses and apoptosis.

The preferred granzyme M antibody is granzyme M Antibody (A-10): sc-376799.