Grancalcin Antibody (D-4): sc-365807

Grancalcin Antibody (D-4) is a mouse monoclonal IgM antibody that detects Grancalcin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Grancalcin is a calcium-binding protein predominantly found in human neutrophils and plays a crucial role in the immune response. Anti-Grancalcin antibody (D-4) belongs to the penta EF-hand subfamily of EF-hand proteins, which includes calpain, sorcin, peflin, and ALG-2. Notably, Grancalcin undergoes significant conformational changes upon calcium binding, which exposes hydrophobic amino acid residues that facilitate interaction with various cellular components. This property is essential for regulating neutrophil adhesion, as Grancalcin interacts with L-plastin, a protein known for actin bundling activity. The ability of Grancalcin to modulate cytoskeletal dynamics is vital for neutrophil migration and function during immune responses. Furthermore, Grancalcin is primarily associated with cells derived from the bone marrow, being particularly abundant in neutrophils and monocytes, while only trace amounts are found in lymphocytes. Grancalcin (D-4) antibody is an invaluable tool for researchers studying this protein′s role in immune cell function and implications in various diseases.

The preferred Grancalcin antibody is Grancalcin Antibody (G-3): sc-365808.