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m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for Glucosidase I Antibody (C-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with Glucosidase I Antibody (C-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Glucosidase I Antibody (C-11) is a high quality monoclonal Glucosidase I antibody (also designated Glucosidase I antibody) suitable for the detection of the Glucosidase I protein of mouse, rat and human origin. Glucosidase I Antibody (C-11) is available as both the non-conjugated anti-Glucosidase I antibody form, as well as multiple conjugated forms of anti-Glucosidase I antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Glycosylation of asparagine residues in Asn-X-Ser/Thr motifs in proteins commonly occur in the lumen of the endoplasmic reticulum (ER). Glucosidase I catalyzes the first step in the N-linked oligosaccharide processing pathway. It specifically removes the distal alpha 1,2-linked glucose residue from the Glc3-Man9-GlcNAc2 oligosaccharide precursor. Glucosidase I contains a short cytosolic tail, a single pass transmembrane domain and a large C-terminal catalytic domain located on the luminal side of the ER. Mutations in the gene encoding Glucosidase I result in the congenital disorder glycosylation (CDG-IIb), which is characterized by generalized hypotonia, dysmorphic features, hepatomegaly, hypoventilation, feeding problems, seizures and death. Two point mutations in the Glucosidase I gene have been identified and result in amino acid substitutions, namely Arg486Thr and Phe652Leu, that affect polypeptide folding and active site formation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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