(+)-Fluprostenol CAS: 54276-17-4
MF: C23H29F3O6
MW: 458.47
A metabolically stable PGF2αR agonist.

(+)-Fluprostenol (CAS 54276-17-4)

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备用名: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid; [1R-[1α(Z),2β(1E,3R*),3α,5α]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid
应用; (+)-Fluprostenol is a metabolically stable PGF2αR agonist
CAS号码: 54276-17-4
纯度: >90%
分子量: 458.47
分子式: C23H29F3O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

(+)-Fluprostenol is the optically active enantiomer of fluprostenol (sc-201336). It is a metabolically stable analog of PGF2α and a potent FP prostanoid receptor (PGF2αR) agonist. The expected potency of (+)-fluprostenol is twice that of (+/-)-fluprostenol for PGF2α binding to human and rat FP receptors. (+)-Fluprostenol is an effective inhibitor of rat adipose precursor differentiation in primary cultures.


参考文献

1. Dukes, M., et al., 1974. Potent luteolytic agents related to prostaglandin F2alpha. Nature. 250(464): 330-1. PMID: 4853720
2. Lake, S., et al., 1994. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. FEBS letters. 355(3): 317-25. PMID: 7988697
3. Abramovitz, M., et al., 1994. Cloning and expression of a cDNA for the human prostanoid FP receptor. The Journal of biological chemistry. 269(4): 2632-6. PMID: 8300593
4. Serrero, G., et al., 1997. Prostaglandin F2alpha receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochemical and biophysical research communications. 233(1): 200-2. PMID: 9144422

规划 :
1% solution in ethanol
物理状态 :
Liquid
保存 :
Store at -20° C
沸点 :
78° C
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
5311100
MDL 号码 :
MFCD00210955
SMILES :
C1[[email protected]@H]([[email protected]@H]([[email protected]]([[email protected]@H]1O)/C=C/[[email protected]](COC2=CC=CC(=C2)C(F)(F)F)O)C/C=C\\CCCC(=O)O)O

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