Flubendazole (CAS 31430-15-6)
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Flubendazole is a potent broad spectrum anthelmintic. It is used in laboratory experiments as an effective tool for the study of biological processes, such as cell growth and differentiation, gene expression, cell signaling pathways, and metabolism. Flubendazole works by inhibiting the polymerization of tubulin, which is necessary for the formation of microtubules. This disrupts the normal functioning of the cell, resulting in cell death. It has also been found to inhibit the activity of acetylcholinesterase, carboxylesterase, and cytochrome P450. Flubendazole is effective against a wide range of parasites, including roundworms, hookworms, and tapeworms, as well as protozoan parasites, such as Giardia, Trichomonas, and Entamoeba.
Flubendazole (CAS 31430-15-6) References
- Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen. | Michaelis, M., et al. 2015. Sci Rep. 5: 8202. PMID: 25644037
- Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells. | Hou, ZJ., et al. 2015. Oncotarget. 6: 6326-40. PMID: 25811972
- Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy. | Čáňová, K., et al. 2017. Acta Medica (Hradec Kralove). 60: 5-11. PMID: 28399389
- Flubendazole induces mitotic catastrophe and apoptosis in melanoma cells. | Čáňová, K., et al. 2018. Toxicol In Vitro. 46: 313-322. PMID: 29107018
- Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis. | Zhou, X., et al. 2018. Cell Death Discov. 4: 18. PMID: 29531815
- Flubendazole as a macrofilaricide: History and background. | Geary, TG., et al. 2019. PLoS Negl Trop Dis. 13: e0006436. PMID: 30650160
- Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer. | Zhen, Y., et al. 2020. Theranostics. 10: 8080-8097. PMID: 32724459
- Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer. | Zhou, X., et al. 2021. Pharmacol Res. 164: 105305. PMID: 33197601
- Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle. | Ren, LW., et al. 2022. Acta Pharmacol Sin. 43: 194-208. PMID: 34433903
- Flubendazole Elicits Antitumor Effects by Inhibiting STAT3 and Activating Autophagy in Non-small Cell Lung Cancer. | Xie, X., et al. 2021. Front Cell Dev Biol. 9: 680600. PMID: 34513827
- Emerging insights on functions of the anthelmintic flubendazole as a repurposed anticancer agent. | Khachigian, LM. 2021. Cancer Lett. 522: 57-62. PMID: 34520820
- Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer. | Zhen, Y., et al. 2022. Cell Death Dis. 13: 375. PMID: 35440104
- Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest. | Vítovcová, B., et al. 2023. Sci Rep. 13: 5993. PMID: 37045903
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Flubendazole, 10 g | sc-204754 | 10 g | $97.00 | |||
Flubendazole, 25 g | sc-204754A | 25 g | $158.00 |