Fisetin CAS: 528-48-3
MF: C15H10O6
MW: 286.24
A potent sirtuin activating compound (STAC), antiinflammatory and anticancer agent.

Fisetin (CAS 528-48-3)

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同义词: 3,3′,4′,7-Tetrahydroxyflavone
应用; A potent sirtuin activating compound (STAC), antiinflammatory and anticancer agent
CAS号码: 528-48-3
纯度: ≥98%
分子量: 286.24
分子式: C15H10O6
* 参考分析证明 大量特定数据 (包括水 含量).
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Fisetin is a flavone which acts as an inhibitor of Akt, Cdk6, mTOR and PI 3-kinase and an activator of ERK. It has been shown to inhibit melanoma cell growth via its mTOR binding activity.

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in water (partly), ethanol (3 mg/ml) at 25° C, acetone, acetic acid, solutions of fixed alklai hydroxides, methanol, ether (very slightly), benzene (very slightly), chloroform (very slightly), hexane (very slightly), petroleum ether (very slightly), DMSO (57 mg/ml) at 25° C, DMF, alcohol, and dilute alcohol/ NaOH showing a dark green fluorescence.
保存 :
Store at 4° C
熔点 :
330° C (dec.)
沸点 :
~599.4° C at 760 mmHg (Predicted)
密度 :
~1.7 g/cm3 (Predicted)
折射率 :
n20D 1.79 (Predicted)
IC50 :
Oxidative degradation of membrane lipids in microsomes: IC50 = 200 nM (rat); Glycogen synthase kinase-3 beta: IC50 = 420 nM (human); Glycogen synthase kinase-3 alpha: IC50 = 420 nM (human); CK2: IC50 = 350 nM (human); Cyclin-dependent kinase 5/CDK5 activator 1: IC50 = 570 nM (human)
Ki 数据 :
Butyrylcholinesterase: Ki= 90 µM (human); Acetylcholinesterase: Ki= 100.2 µM (human)
pK值 :
pKa: 6.83 (Predicted)
仅供科研使用。不可用于诊断或治疗。
RTECS :
LK9250000
PubChem CID :
5281614
默克索引 :
14: 4088
MDL 号码 :
MFCD00006829
EC号码 :
208-434-4
Beilstein 注册 :
292829
SMILES :
C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O

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引用1 - 22

PMID: # 26408178  Adan, A. et al. 2016. Tumour Biol. 37: 5781-95.

PMID: # 27489195  Sak, K. et al. 2016. Food Funct. 7: 3815-24.

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