Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

Filamin 1 抗体 (E-3): sc-17749

4.9(16)
寫評論提問

说明书
  • Filamin 1 抗体 E-3 是小鼠单克隆 IgG2a κ,Filamin 1抗体, 在46篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Filamin 1的N-terminus附近的氨基酸9-27之间
  • Filamin 1 抗体 (E-3) 推荐用于 WB, IP, IF 和 IHC(P),检测mouse, rat 和human 来源的 Filamin 1
  • 抗Filamin 1抗体(E-3)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Filamin 1 (E-3): sc-17749免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRPm-IgGκ BP-HRP 是 Filamin 1 抗体 (E-3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Filamin 1 抗体 (E-3) 组合成套装提供。 (请参阅下面的订购信息)。

快捷链接

関連項目

丝连蛋白1抗体(E-3)是一种小鼠单克隆IgG2a kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和免疫组织化学检测小鼠、大鼠和人类丝连蛋白1蛋白。抗丝连蛋白1抗体(E-3)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。丝蛋白1通过交联肌动蛋白丝在组织细胞骨架中发挥关键作用,而肌动蛋白丝对于维持细胞形状、运动和机械稳定性至关重要。丝蛋白1主要位于细胞质中,形成同二聚体,从而形成支持细胞结构的网络。丝蛋白1的功能对于细胞迁移和信号转导等多种细胞过程至关重要,失调与多种疾病有关,包括心肌病和某些癌症。丝连蛋白1与多种蛋白相互作用,例如整合素和生长因子受体,这进一步强调了其在细胞信号传导通路和结构完整性中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Filamin 1 抗体 (E-3) 参考文献:

  1. 小鼠消化道和泌尿道上皮细胞系中绒毛蛋白基因表达的发育调控。  |  Maunoury, R., et al. 1992. Development. 115: 717-28. PMID: 1425351
  2. Caldesmon 可与平滑肌肌球蛋白和肌球蛋白杆结合,并使粗丝与肌动蛋白丝交联。  |  Marston, S., et al. 1992. J Muscle Res Cell Motil. 13: 206-18. PMID: 1534566
  3. 丝胺 A 功能的结构基础  |  Nakamura, F., et al. 2007. J Cell Biol. 179: 1011-25. PMID: 18056414
  4. 在一个患有双侧脑室周围结节性异位症(BPNH)的家族中,FLNA基因中发现了一种新的错义突变,改变了剪接过程。  |  Tsuneda, SS., et al. 2008. J Mol Neurosci. 35: 195-200. PMID: 18427995
  5. ECSM2 是一种内皮特异性丝胺 a 结合蛋白,可介导趋化作用。  |  Armstrong, LJ., et al. 2008. Arterioscler Thromb Vasc Biol. 28: 1640-6. PMID: 18556573
  6. [作为癌细胞变化介质的纤 维素 A]  |  Wieczorek, K. and Niewiarowska, J. 2014. Postepy Biochem. 60: 77-83. PMID: 25033545
  7. HeLa 细胞丝胶的肌动蛋白结合和二聚化结构域。  |  Weihing, RR. 1988. Biochemistry. 27: 1865-9. PMID: 3378035
  8. 小鼠平滑肌细胞中丝胶素 A 的缺乏可防止缺氧介导的肺动脉高压。  |  Zheng, Y., et al. 2023. Int J Mol Med. 51: PMID: 36704846
  9. 丝胶素 A 与人类肝内胆管癌的侵袭性和进展有关。  |  Vitali, E., et al. 2024. Liver Int. 44: 518-531. PMID: 38010911
  10. 人类球蛋白的完整一级结构及其与肌肉结构的相关性。  |  Labeit, S. and Kolmerer, B. 1995. J Mol Biol. 248: 308-15. PMID: 7739042
  11. Caldesmon 与 Ca(2+)-calmodulin 的多位相互作用。  |  Huber, PA., et al. 1996. Biochem J. 316 (Pt 2): 413-20. PMID: 8687382
  12. 克隆小鼠球蛋白的 cDNA。证明神经球蛋白编码序列在脊椎动物中高度保守。  |  Zhang, JQ., et al. 1996. Eur J Biochem. 239: 835-41. PMID: 8774733

订购信息

产品名称产品编号规格价格数量收藏夹

Filamin 1 抗体 (E-3)

sc-17749
200 µg/ml
$316.00

Filamin 1 (E-3): m-IgG Fc BP-HRP 套装

sc-528293
200 µg Ab; 10 µg BP
$354.00

Filamin 1 (E-3): m-IgGκ BP-HRP 套装

sc-520634
200 µg Ab, 40 µg BP
$354.00

Filamin 1 (E-3): m-IgG2a BP-HRP 套装

sc-547060
200 µg Ab; 10 µg BP
$354.00

Filamin 1 抗体 (E-3) AC

sc-17749 AC
500 µg/ml, 25% agarose
$416.00

Filamin 1 抗体 (E-3) HRP

sc-17749 HRP
200 µg/ml
$316.00

Filamin 1 抗体 (E-3) FITC

sc-17749 FITC
200 µg/ml
$330.00

Filamin 1 抗体 (E-3) PE

sc-17749 PE
200 µg/ml
$343.00

Filamin 1 抗体 (E-3) Alexa Fluor® 488

sc-17749 AF488
200 µg/ml
$357.00

Filamin 1 抗体 (E-3) Alexa Fluor® 546

sc-17749 AF546
200 µg/ml
$357.00

Filamin 1 抗体 (E-3) Alexa Fluor® 594

sc-17749 AF594
200 µg/ml
$357.00

Filamin 1 抗体 (E-3) Alexa Fluor® 647

sc-17749 AF647
200 µg/ml
$357.00

Filamin 1 抗体 (E-3) Alexa Fluor® 680

sc-17749 AF680
200 µg/ml
$357.00

Filamin 1 抗体 (E-3) Alexa Fluor® 790

sc-17749 AF790
200 µg/ml
$357.00

Filamin 1 (E-3) 中和勝肽

sc-17749 P
100 µg/0.5 ml
$68.00

Do you have any data validating the specificity of this Filamin 1 (E-3): sc-17749 monoclonal antibody?

Asked by: cjMara
Yes, we have siRNA knockdown data published on our website using our Filamin 1 siRNA (h): sc-35374 transfected into HeLa cells. Protein knockdown was observed by Western blot and immunofluorescence using this antibody.
Answered by: Technical Support
Date published: 2017-01-27
  • y_2025, m_8, d_28, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_17749, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 106ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from very good signal for WBThe Ab works very well, clear bands. Used on colorectal cancer stem cells.
Date published: 2021-07-06
Rated 5 out of 5 by from Good for both IF and WBThis antibody worked perfectly in IF and WB both for different human melanoma cell lines (MDA-MB-435S and RPMI-7951). It showed differential expression among the cell lines and the expression was in line with the mass spectrometry results.
Date published: 2021-06-07
Rated 5 out of 5 by from WBThis antibody is very good for western blot. The band is very clear.
Date published: 2017-12-08
Rated 5 out of 5 by from I think the antibody is good to useI only used twice, WB to show a good band, I am very satisfied
Date published: 2017-09-04
Rated 5 out of 5 by from Great Featureswork well in WB at 1:500 ,NB4 cell.but the transmembrane time is particularly long.three are trends we want.thank you
Date published: 2017-05-28
Rated 5 out of 5 by from Work good in HAEC cellsIt is a good ab for western blot, with 1:200 dilution.
Date published: 2017-05-26
Rated 5 out of 5 by from Excellent for WBExcellent for WB , will purchase it in the future .
Date published: 2017-04-13
Rated 5 out of 5 by from Highly recommended Filamin 1 monoclonalThis well characterized Filamin 1 monoclonal performs strong in a wide variety of applications on mouse, rat and human samples.
Date published: 2016-12-30
  • y_2025, m_8, d_28, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_16
  • loc_zh_CN, sid_17749, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
Filamin 1 抗体 (E-3) is rated 4.9 out of 5 by 16.
  • y_2025, m_8, d_28, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_16
  • loc_zh_CN, sid_17749, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 101ms
  • REVIEWS, PRODUCT