Date published: 2025-9-7

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Fibrinogen α 抗体 (C-7): sc-398806

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说明书
  • Fibrinogen alpha 抗体 C-7 是小鼠单克隆 IgG2b κ,Fibrinogen α抗体, 在10篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Fibrinogen α的内部区域内的氨基酸581-607之间
  • Fibrinogen alpha 抗体 (C-7) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Fibrinogen isoforms α and α-E
  • 抗Fibrinogen alpha抗体(C-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Fibrinogen α (C-7): sc-398806免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2b BP-HRP">m-IgG2b BP-HRP是Fibrinogen α Antibody (C-7) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与Fibrinogen α Antibody (C-7) 打包提供(请参阅下面的订购信息)。

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関連項目

纤维蛋白原α抗体(C-7)是一种IgG2bκ型小鼠单克隆纤维蛋白原α抗体(也称为FGA抗体、纤维蛋白原α链抗体或纤维蛋白肽A抗体),可通过蛋白质印迹、免疫沉淀、免疫荧光和酶联免疫吸附试验检测小鼠、大鼠和人类来源的纤维蛋白原α蛋白。纤维蛋白原α抗体(C-7)既以非共轭的抗纤维蛋白原α抗体形式存在,也以包括琼脂糖、辣根过氧化物酶、藻红蛋白、异硫氰酸荧光素和多种Alexa Fluor®偶联物在内的多种共轭形式的抗纤维蛋白原α抗体形式存在。血浆糖蛋白纤维蛋白原在肝脏中合成,由三个结构不同的亚基组成:α、β和γ。纤维蛋白原在血小板聚集、凝血级联的最终步骤(即纤维蛋白的形成)以及血浆粘度和红细胞聚集的测定中起重要作用。它既在急性期反应中持续表达,也可被诱导表达。组织损伤后的止血过程需要关键的血浆促凝血因子(凝血酶和因子X、IX、V和VIII)的参与,这些因子参与血液凝固级联反应,导致不溶性纤维蛋白凝块的形成和促进血小板聚集。血管损伤后,纤维蛋白原被凝血酶裂解形成纤维蛋白,这是血凝块中最丰富的成分。纤维蛋白原的裂解产物调节细胞粘附和扩散,显示血管收缩和趋化活性,并对多种细胞类型具有促有丝分裂的作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Fibrinogen α 抗体 (C-7) 参考文献:

  1. 一个英国家庭中由 Glu526Val 纤维蛋白原α-链变异体引起的系统性淀粉样变性病的治愈性肝肾移植。  |  Gillmore, JD., et al. 2000. QJM. 93: 269-75. PMID: 10825402
  2. 血液流变学, 心血管风险因素和心血管疾病:苏格兰西部冠心病预防研究。  |  Lowe, G., et al. 2000. Thromb Haemost. 84: 553-8. PMID: 11057849
  3. 纤维蛋白原--血管疾病的标记物还是介质?  |  Reinhart, WH. 2003. Vasc Med. 8: 211-6. PMID: 14989564
  4. 凝血级联:启动, 维持和调节。  |  Davie, EW., et al. 1991. Biochemistry. 30: 10363-70. PMID: 1931959
  5. 血栓栓塞症儿童的纤溶酶原α和γ基因以及因子VLeiden:两项基于家族的关联研究的结果。  |  Nowak-Göttl, U., et al. 2009. Blood. 114: 1947-53. PMID: 19515723
  6. 慢性血栓栓塞性肺动脉高压的易感性可能是由 miR-759 通过其与多态性纤维蛋白原α基因的靶向相互作用而赋予的。  |  Chen, Z., et al. 2010. Hum Genet. 128: 443-52. PMID: 20677013
  7. 针对通过血清蛋白质组分析检测到的 5.9 kDa 纤维蛋白原 alpha C 链片段开发夹心 ELISA。  |  Noda, K., et al. 2011. Proteomics Clin Appl. 5: 141-6. PMID: 21360827
  8. 血液凝固的基本机制  |  Davie, EW. and Fujikawa, K. 1975. Annu Rev Biochem. 44: 799-829. PMID: 237463
  9. 在实验小鼠模型中,miR-451 的缺乏与子宫内膜纤维蛋白原α链表达的改变和子宫内膜植入的减少有关。  |  Nothnick, WB., et al. 2014. PLoS One. 9: e100336. PMID: 24937656
  10. 钩端螺旋体免疫球蛋白样蛋白B(LigB)与纤溶酶原αC结构域和因子XIII的C终止子23个氨基酸结合:洞察 LigB 介导的纤维蛋白原 α 链交联阻断机制。  |  Hsieh, CL., et al. 2016. PLoS Negl Trop Dis. 10: e0004974. PMID: 27622634
  11. 纤维蛋白原, C 反应蛋白, 白蛋白或白细胞计数与冠心病的缔合作用:前瞻性研究的荟萃分析间。  |  Danesh, J., et al. 1998. JAMA. 279: 1477-82. PMID: 9600484

订购信息

产品名称产品编号规格价格数量收藏夹

Fibrinogen α 抗体 (C-7)

sc-398806
200 µg/ml
$316.00

Fibrinogen α (C-7): m-IgG Fc BP-HRP 套装

sc-526325
200 µg Ab; 10 µg BP
$354.00

Fibrinogen α (C-7): m-IgG2b BP-HRP 套装

sc-549713
200 µg Ab; 10 µg BP
$354.00

Fibrinogen α 抗体 (C-7) AC

sc-398806 AC
500 µg/ml, 25% agarose
$416.00

Fibrinogen α 抗体 (C-7) HRP

sc-398806 HRP
200 µg/ml
$316.00

Fibrinogen α 抗体 (C-7) FITC

sc-398806 FITC
200 µg/ml
$330.00

Fibrinogen α 抗体 (C-7) PE

sc-398806 PE
200 µg/ml
$343.00

Fibrinogen α 抗体 (C-7) Alexa Fluor® 488

sc-398806 AF488
200 µg/ml
$357.00

Fibrinogen α 抗体 (C-7) Alexa Fluor® 546

sc-398806 AF546
200 µg/ml
$357.00

Fibrinogen α 抗体 (C-7) Alexa Fluor® 594

sc-398806 AF594
200 µg/ml
$357.00

Fibrinogen α 抗体 (C-7) Alexa Fluor® 647

sc-398806 AF647
200 µg/ml
$357.00

Fibrinogen α 抗体 (C-7) Alexa Fluor® 680

sc-398806 AF680
200 µg/ml
$357.00

Fibrinogen α 抗体 (C-7) Alexa Fluor® 790

sc-398806 AF790
200 µg/ml
$357.00

Fibrinogen α (C-7) 中和勝肽

sc-398806 P
100 µg/0.5 ml
$68.00

Is it correct that the antigen sequence (581-607) is QFTSSTSYNRGDSTFESKSYKMADEA of human fibrinogen alpha chain (UniProt: P02671)?

Asked by: Tomoaki
Thank you for your question. The antigen sequence(581-607) is KQFTSSTSYN RGDSTFESKS YKMADEA of human fibrinogen alpha chain (UniProt: P02671). Please contact our Technical Service Department if you have any other questions. Our Asian Technical Service team is available at (+86) 021-60936350 or asia@scbio.cn or by live chat on our website.
Answered by: Sen Li
Date published: 2022-03-03

Can fibrin be detected with this antibody?

Asked by: KY1111
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

According to datasheat, I just confused to know what is actual molecular weight of fibrinogen alpha. Why so much non specific band comes in western blot.

Asked by: Rajkamal
Thank you for your question. Fibrinogen α has two isoforms (with molecular weights of 95 kDa and 70 kDa, respectively) as well as a large number of amino acid modifications which may contribute to differences in observed molecular weight in western blots — the different signals are not unspecific but rather differently modified variants of the Fibrinogen α isoforms.
Answered by: Technical Support Europe
Date published: 2020-10-08

What application is the blocking peptide sc-398806 P appropriate for?

Asked by: Cweed
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from This antibody is a pretty good one.We just followed a standard procedure for a western blot analysis of fibrinogen alpha expression and found that the antibody worked very well with brain tissues.
Date published: 2017-11-21
Rated 5 out of 5 by from Nice specific signalGreat signal with IHC/IF on formal fixed paraffin embedded brain tissue
Date published: 2017-11-19
Rated 5 out of 5 by from Great feature!I tried a free sample of this antibody in flow cytometry to detect human platelet-released fibrinogen. Very nice shift!
Date published: 2016-11-18
Rated 5 out of 5 by from Very good Western blot data of FibrinogenVery good Western blot data of Fibrinogen expression in Hep G2 whole cell lysate, human liver tissue extract and human platelet extract . -SCBT QC
Date published: 2013-09-27
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Fibrinogen α 抗体 (C-7) is rated 5.0 out of 5 by 4.
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