Farnesylthioacetic Acid (FTA) CAS: 135784-48-4
MF: C17H28O2S
MW: 296.5
An inhibitor of Ca2+ influx through non-voltage-gated Ca2+ channels.

Farnesylthioacetic Acid (FTA) (CAS 135784-48-4)

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应用; An inhibitor of Ca2+ influx through non-voltage-gated Ca2+ channels
CAS号码: 135784-48-4
分子量: 296.5
分子式: C17H28O2S
* 参考分析证明 大量特定数据 (包括水 含量).
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FTA has shown potent and specifc inhibition of methyl esterification of farnesylated and geranylgeranylated proteins. It has inhibited Ca2+ influx through non-voltage-gated Ca2+ channels. FTA also has the property to be a TRPA1 agonist.


参考文献

1. Uyesaka, N. 1977. J. Membr. Biol. 30: 403. PMID: 190405
2. Volker, C., et al. 1991. FEBS Lett. 295: 189-194. PMID: 1765152
3. Pérez-Sala, D., et al. 1992. Biochem. J. 284: 835-840. PMID: 1622400
4. Xu, Y., et al. 1996. Mol. Pharmacol. 50: 1495-1501. PMID: 8967970
5. Maher, M., et al. 2008. Mol. Pharmacol. 7: 1225-1234. PMID: 18171730

外观 :
Oil
溶解度 :
Soluble in DMSO (>25 mg/mL) and ethanol (>25 mg/mL)
保存 :
Store at -20° C
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
3328
SMILES :
CC(=CCCC(=CCCC(=CCSCC(=O)O)C)C)C

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