Farnesyl pyrophosphate ammonium salt, in ethanol CAS: 13058-04-3
MF: C15H25O7P2•3NH4
MW: 433.42
An isoprenoid farnesyl donor.

Farnesyl pyrophosphate ammonium salt, in ethanol (CAS 13058-04-3)

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同义词: FPP.3NH4
应用; An isoprenoid farnesyl donor
CAS号码: 13058-04-3
纯度: ≥98%
分子量: 433.42
分子式: C15H25O7P23NH4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
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Farnesyl pyrophosphate ammonium salt, in ethanol, is an isoprenoid farnesyl-donor which is utilized by farnesyltransferase. It is also used for prenylation of several low molecular mass G proteins, including Ras. FPP has been shown to negate the inhibitory effects of cell growth for cells grown in high glucose conditions as well as to reverse the growth inhibitory effects of statins on variant human embryonic stem cells and cancer cells. FPP has also been detected in Alzheimer′s patients brains in elevated levels. Farnesyl pyrophosphate ammonium salt is an inhibitor of P2Y12. Concentration: 2 mg/mL in 0.25M ammonium bicarbonate containing 70% ethanol.


参考文献

1. Pompliano, D.L., et al. 1992. Biochemistry. 31: 3800-3807. PMID: 1567835
2. Reiss, Y., et al. 1992. J. Biol. Chem. 267: 6403-6408. PMID: 1556143
3. Gauthaman, K., et al. 2009. Br. J. Pharmacol. 157: 962-973. PMID: 19438511
4. Ye, Y., et al. 2009. FEBS Lett. 583: 2997-3003. PMID: 19716825
5. Mather, A., et al. 2009. Int. J. Biochem. Cell Biol. 41: 561-569. PMID: 18692592
6. Hooff, G.P., et al. 2010. Biochim Biophys Acta.180: 896-905. PMID: 20382260

用法 :
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
规划 :
0.25M ammonium bicarbonate containing 70% ethanol
物理状态 :
Liquid
溶解度 :
Soluble in water.
保存 :
Store at -20° C
沸点 :
78° C
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
1
PubChem CID :
71299715
MDL 号码 :
MFCD00189688
SMILES :
CC(=CCC/C(=C/CC/C(=C/COP(=O)(O)OP(=O)(O)O)/C)/C)C.N.N.N

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