Date published: 2025-9-7
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FAAH Antibody (27-Y) - Western Blotting - Image 368183
FAAH 抗体 (27-Y): sc-100739. A-431 (A) 和 c4 (B) 全细胞裂解液中 FAAH 表达的 Western 印迹分析.
FAAH 抗体 (27-Y): sc-100739. A-431 (A) 和 c4 (B) 全细胞裂解液中 FAAH 表达的 Western 印迹分析.

FAAH 抗体 (27-Y): sc-100739

4.8(4)
寫評論提問

说明书
  • FAAH 抗体 27-Y 是小鼠单克隆 IgG2a κ，FAAH抗体, 在14篇文献中引用，规格为100 µg/ml
  • 与human起源的FAAH的C-terminus区域
  • 推荐用于 mouse, rat 和 human 来源的FAAH WB, IP 和 ELISA检测
  • 关于如何获取FAAH (27-Y): sc-100739的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成FAAH 抗体 (27-Y)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

FAAH抗体（27-Y）是一种IgG2a κ小鼠单克隆抗体，可通过WB、IP和ELISA方法检测小鼠、大鼠和人源的FAAH蛋白。FAAH抗体（27-Y）可以作为非偶联的抗FAAH抗体使用。FAAH（脂肪酸酰胺水解酶）是一种膜结合酶，负责水解多种一级和二级脂肪酸酰胺，包括神经调节化合物阿南达胺和油酰胺。将花生四烯酸酰胺降解为花生四烯酸，油酰胺降解为油酸的过程，终止了这些分子的信号传导功能。FAAH以等效的催化效率降解酰胺和酯，因此既可以作为酰胺酶也可以作为酯酶有效发挥作用。FAAH通过创造并维持阿南达胺的内向浓度梯度，促进阿南达胺的摄取。人类FAAH基因中天然存在的单核苷酸多态性突变在其纯合形式下与问题药物使用密切相关。这导致错义突变(385C-->A)，将保守的脯氨酸残基转化为苏氨酸(Pro129-->Thr)，产生显示正常催化特性但对蛋白水解降解敏感性增强的FAAH变体。因此，FAAH中的基因突变是问题药物使用的重要危险因素。人类FAAH基因定位于染色体1p33。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

FAAH 抗体 (27-Y) 参考文献:

  1. 脂肪酸酰胺水解酶通过一种非常规催化机制竞争性地降解生物活性酰胺和酯。  |  Patricelli, MP. and Cravatt, BF. 1999. Biochemistry. 38: 14125-30. PMID: 10571985
  2. 脂肪酸酰胺水解酶在转运内源性大麻酰胺中的作用。  |  Day, TA., et al. 2001. Mol Pharmacol. 59: 1369-75. PMID: 11353795
  3. 与问题药物使用有关的人类脂肪酸酰胺水解酶错义突变。  |  Sipe, JC., et al. 2002. Proc Natl Acad Sci U S A. 99: 8394-9. PMID: 12060782
  4. CNR1和FAAH变异与吸食大麻诱发的情感状态。  |  Palmer, RHC., et al. 2019. Am J Drug Alcohol Abuse. 45: 514-526. PMID: 31184938
  5. FAAH水平及其基因多态性与甲基苯丙胺依赖性易感性的关系。  |  Zhang, W., et al. 2020. Ann Hum Genet. 84: 259-270. PMID: 31789429
  6. FAAH 基因变异对创伤后应激障碍女性恐惧获得和消退学习的生理、认知和神经特征的影响。  |  Crombie, KM., et al. 2022. Neuroimage Clin. 33: 102922. PMID: 34952353
  7. 一氧化氮在体外通过 FAAH 和 NAPE-PLD 积极影响子宫内膜的接受能力。  |  Melford, SE., et al. 2021. Reprod Fertil. 2: 107-116. PMID: 35128447
  8. 脂肪酸酰胺水解酶（FAAH）的遗传变异会加剧激素介导的小鼠促厌食。  |  Balsevich, G., et al. 2023. Elife. 12: PMID: 37039453
  9. FAAH 基因的功能变异与主观幸福感直接相关，而与问题性饮酒间接相关。  |  Bornscheuer, L., et al. 2023. Genes (Basel). 14: PMID: 37761966
  10. 抑制 FAAH 可改善小鼠模型中的乳腺癌。  |  Tripathy, M., et al. 2023. Oncotarget. 14: 910-918. PMID: 37921652
  11. 降解神经调节脂肪酸酰胺酶的分子特征。  |  Cravatt, BF., et al. 1996. Nature. 384: 83-7. PMID: 8900284
  12. 人类和小鼠脂肪酸酰胺水解酶的分子特征。  |  Giang, DK. and Cravatt, BF. 1997. Proc Natl Acad Sci U S A. 94: 2238-42. PMID: 9122178

订购信息

产品名称产品编号规格价格数量收藏夹

FAAH 抗体 (27-Y)

sc-100739
100 µg/ml
$333.00

Hello, we were using sc-26427 and an APC conjugated secondary antibody to detect FAAH by flow. However, sc-26427 was discontinued (we are mid study) and replaced by sc-100739. Can you suggest a replacement secondary APC or supply the original Ab?

Asked by: Rachel Schirer
Thank you for your question. We can offer secondary antibodies conjugated to APC as a special order. Please contact our Technical Service Department to request more detailed information. Please call us toll-free at (800) 457-3801 option 2, or e-mail <specialorders@scbt.com>. Unfortunately, we are unable to provide the goat polyclonal antibody, sc-26427. However, we can provide a free 10 µg sample of the recommended replacement mouse monoclonal antibody, FAAH (27-Y): sc-100739. Please contact Technical Service to request a free sample.
Answered by: Technical Support
Date published: 2017-06-22

For Western Blot, is it recommended to use denatured or non-denatured conditions with FAAH (27-Y): sc-100739 antibody?

Asked by: Cweed
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from ExcellentA free sample of the antibody has been tested and it was very effective for detecting FAAH in samples from rat hippocampus
Date published: 2022-11-03
Rated 5 out of 5 by from Great feature！I brought it last year and the western blot results were good every time.
Date published: 2019-04-26
Rated 5 out of 5 by from Good for Western BlotGreat antibody for detecting endogenous FAAH and cells transfected with cDNA to over-express FAAH in Western Blot.
Date published: 2017-02-08
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FAAH 抗体 (27-Y) is rated 4.8 out of 5 by 4.
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