Entecavir CAS: 142217-69-4
MF: C12H15N5O3
MW: 277.28
A guanine analog that inhibits reverse transcription.

Entecavir (CAS 142217-69-4)

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同义词: 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one
应用; A guanine analog that inhibits reverse transcription
CAS号码: 142217-69-4
纯度: ≥99%
分子量: 277.28
分子式: C12H15N5O3
* 参考分析证明 大量特定数据 (包括水 含量).
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Entecavir is a deoxyguanosine nucleoside analogue with antiviral activity against the hepatitis B virus (HBV). The compound has a mechanism of action by inhibiting priming and chain extension through inhibition of HBV DNA polymerase. Entecavir is also documented as the most potent HBV DNA polymerase inhibitor and superior to Lamivudine (sc-221830) due to its effectiveness against Lamivudine resistant HBV strains and being 30 fold more active.


参考文献

1. Thomas, H., et al. 2003. J. Hepatol. 39: S93-S98. PMID: 14708685
2. Rivkin, A. 2007. Drugs Today. 43: 201-220. PMID: 17460784

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in water (2.2-3 mg/ml), DMSO, and methanol.
保存 :
Store at room temperature
熔点 :
238-244° C
沸点 :
661.40° C at 760 mmHg (Predicted)
密度 :
1.81 g/cm3 (Predicted)
折射率 :
n20D 1.84 (Predicted)
光学活性 :
α20/D +36.8°, c = 0.1 in methanol
IC50 :
Human immunodeficiency virus: EC5050 = 0.1 nM; Hepatitis B virus: EC5050 = 2.4 nM; HepG2: EC5050 = 3 nM (human); HIV-1: EC5050 = 9 µM (MT-2); HIV-PSEUDOTYPED NL4-3: EC5050 = 12.6 µM (HEK-293)
pK值 :
pKa: 9.64 (Predicted), pKb: 2.64 (Predicted)
仅供科研使用。不可用于诊断或治疗。
RTECS :
UP0789600
PubChem CID :
153941
MDL 号码 :
MFCD00907887
Beilstein 注册 :
7692760
SMILES :
C=C1[[email protected]](C[[email protected]@H]([[email protected]]1CO)O)N2C=NC3=C2NC(=NC3=O)N

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引用1 - 88

PMID: # 30671048  Fukano, K. et al. 2018. Front Microbiol. 9: 3257.

PMID: # 29779957  2018. Cell Chem Biol. 25: 906-915.e5.

PMID: # 28363866  Haga, Y. et al. 2017. Biochem. Biophys. Res. Commun. 486: 858-863.

PMID: # 26779022  Mandíková, J. et al. 2015. Frontiers in pharmacology. 6: 304.

PMID: # 25550158  Tsukuda, S. et al. 2015. J. Biol. Chem. 290: 5673-84.

PMID: # 24126184  Vlčková, H. et al. 2014. J Pharm Biomed Anal. 88: 337-44.

PMID: # 24025329  Watashi, K. et al. 2013. J. Biol. Chem. 288: 31715-27.

PMID: # 22520634  Nováková, L. et al. 2012. J Chromatogr A. 1259: 237-43.

引用1 - 88
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