Date published: 2025-9-7

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EMMPRIN/CD147 抗体 (8D6): sc-21746

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说明书
  • EMMPRIN/CD147 抗体 8D6 是小鼠单克隆 IgG1 κ,EMMPRIN/CD147抗体, 在60篇文献中引用,规格为200 µg/ml
  • 针对human T细胞白血病细胞系,Peer
  • EMMPRIN/CD147 抗体 (8D6) 推荐用于WB, IP, IF, IHC(P) 和 FCM,检测human 来源的 EMMPRIN
  • 抗EMMPRIN/CD147抗体(8D6)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取EMMPRIN/CD147 (8D6): sc-21746免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 EMMPRIN/CD147 抗体 (8D6) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与EMMPRIN/CD147 抗体 (8D6) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

EMMPRIN抗体(8D6)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和流式细胞术(FCM)检测人源EMMPRIN蛋白。EMMPRIN (8D6) 抗体有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。EMMPRIN蛋白(又称basigin或CD147)在表皮-真皮交界处的基质重塑调节中起着至关重要的作用,而基质重塑对于维持皮肤完整性和促进伤口愈合至关重要。EMMPRIN可刺激成纤维细胞产生基质金属蛋白酶(MMP),如间质胶原酶、明胶酶A和基质蛋白酶-1,这些酶在正常生理过程和病理条件下(包括癌症侵袭和转移)的组织重塑中至关重要。EMMPRIN能够调节MMP活性,这凸显了它在组织稳态和各种疾病进展中的重要性,使得抗EMMPRIN抗体(8D6)成为研究人员研究这些关键生物学过程的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

EMMPRIN/CD147 抗体 (8D6) 参考文献:

  1. 基质金属蛋白酶及其抑制剂在肿瘤生长和侵袭中的作用。  |  Kähäri, VM. and Saarialho-Kere, U. 1999. Ann Med. 31: 34-45. PMID: 10219712
  2. CD147 的 T 细胞活化缔合作用表位在调节 T 细胞反应中的作用,以及抗体亲和力和抗原密度对它们的定义。  |  Koch, C., et al. 1999. Int Immunol. 11: 777-86. PMID: 10330283
  3. VEGF和EMMPRIN表达与骨肉瘤患者的存活率相关。  |  Zhou, Q., et al. 2011. Surg Oncol. 20: 13-9. PMID: 19836228
  4. Basigin 是免疫球蛋白超家族中分布广泛的新成员,与免疫球蛋白 V 结构域和主要组织相容性复合体 II 类抗原的 beta 链都有很强的同源性。  |  Miyauchi, T., et al. 1990. J Biochem. 107: 316-23. PMID: 2361961
  5. EMMPRIN,MMP的上游调节因子,在中枢神经系统生物学中的作用。  |  Kaushik, DK., et al. 2015. Matrix Biol. 44-46: 138-46. PMID: 25644103
  6. 活化大鼠 T 淋巴细胞的抗原,包括仅在 CD4 阳性 T 细胞上检测到的 50,000 摩尔。  |  Paterson, DJ., et al. 1987. Mol Immunol. 24: 1281-90. PMID: 2828930
  7. EMMPRIN是一种能够调节癌症特征的新兴蛋白。  |  de la Cruz Concepción, B., et al. 2022. Eur Rev Med Pharmacol Sci. 26: 6700-6724. PMID: 36196720
  8. 人类肿瘤细胞衍生胶原酶刺激因子(更名为 EMMPRIN)是免疫球蛋白超家族的成员。  |  Biswas, C., et al. 1995. Cancer Res. 55: 434-9. PMID: 7812975
  9. 人类角朊细胞表达 EMMPRIN,这是一种细胞外基质金属蛋白酶诱导剂。  |  DeCastro, R., et al. 1996. J Invest Dermatol. 106: 1260-5. PMID: 8752667
  10. 转染中国仓鼠卵巢细胞的重组细胞外基质金属蛋白酶诱导剂刺激基质金属蛋白酶的产生。  |  Guo, H., et al. 1997. J Biol Chem. 272: 24-7. PMID: 8995219
  11. 人类 EMMPRIN(一种肿瘤细胞表面基质金属蛋白酶诱导剂)基因的特征。  |  Guo, H., et al. 1998. Gene. 220: 99-108. PMID: 9767135
  12. 源自肿瘤的 EMMPRIN(细胞外基质金属蛋白酶诱导剂)通过 MAPK p38 刺激胶原酶转录。  |  Lim, M., et al. 1998. FEBS Lett. 441: 88-92. PMID: 9877171

订购信息

产品名称产品编号规格价格数量收藏夹

EMMPRIN/CD147 抗体 (8D6)

sc-21746
200 µg/ml
$316.00

EMMPRIN/CD147 (8D6): m-IgG Fc BP-HRP 套装

sc-526609
200 µg Ab; 10 µg BP
$354.00

EMMPRIN/CD147 (8D6): m-IgG1 BP-HRP 套装

sc-531982
200 µg Ab; 20 µg BP
$354.00

EMMPRIN/CD147 抗体 (8D6) AC

sc-21746 AC
500 µg/ml, 25% agarose
$416.00

EMMPRIN/CD147 抗体 (8D6) HRP

sc-21746 HRP
200 µg/ml
$316.00

EMMPRIN/CD147 抗体 (8D6) FITC

sc-21746 FITC
200 µg/ml
$330.00

EMMPRIN/CD147 抗体 (8D6) PE

sc-21746 PE
200 µg/ml
$343.00

EMMPRIN/CD147 抗体 (8D6) Alexa Fluor® 488

sc-21746 AF488
200 µg/ml
$357.00

EMMPRIN/CD147 抗体 (8D6) Alexa Fluor® 546

sc-21746 AF546
200 µg/ml
$357.00

EMMPRIN/CD147 抗体 (8D6) Alexa Fluor® 594

sc-21746 AF594
200 µg/ml
$357.00

EMMPRIN/CD147 抗体 (8D6) Alexa Fluor® 647

sc-21746 AF647
200 µg/ml
$357.00

EMMPRIN/CD147 抗体 (8D6) Alexa Fluor® 680

sc-21746 AF680
200 µg/ml
$357.00

EMMPRIN/CD147 抗体 (8D6) Alexa Fluor® 790

sc-21746 AF790
200 µg/ml
$357.00

This antibody identifies all BSG isoforms?

Asked by: Paco1987
Thank you for your question. EMMPRIN/CD147 Antibody (8D6) is recommended for detection of EMMPRIN of human origin by WB, IP, IF, IHC(P) and FCM. It is not isoform-specific.
Answered by: Tech Support Europe
Date published: 2025-01-16

What is the epitope recognized by EMMPRIN Antibody (8D6): sc-21746?

Asked by: cjMara
EMMPRIN Antibody (8D6) is a mouse monoclonal raised against human T-cell leukemic cell line, Peer. The exact epitope has not been determined.
Answered by: Technical Support 8
Date published: 2017-01-09
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Rated 5 out of 5 by from Works wellI used the antibody for Western Blot and seems to be very specific
Date published: 2021-12-14
Rated 4 out of 5 by from Good AntibodyI bought this Ab 1 month ago, performed in WB, the signal resembles the picture showed in the description. IF and IHC also worked well. I recommend it.
Date published: 2021-11-29
Rated 5 out of 5 by from great!bought this recently really excited to use it seems perfect
Date published: 2020-12-03
Rated 5 out of 5 by from OutstandingClear western blot data; strong, specific signal; also great IHC and IF staining data
Date published: 2017-01-26
Rated 5 out of 5 by from Great antibody for Westerns and IHCThis antibody is well-cited for a variety of applications including WB, IP, IF, and even IHC and Flow. Strong, clear signal with little to no background. Beautiful tissue staining.
Date published: 2017-01-06
Rated 5 out of 5 by from Used for IF/WB with OVCARUsed for IF/WB with OVCAR-3, A2780, metastatic (SKOV-3, OV-90) EOC cell lines, and Epithelial ovarian cancer tissue. -SCBT Publication Review
Date published: 2015-05-08
Rated 5 out of 5 by from Produced exceptional immunoperoxidase membraneProduced exceptional immunoperoxidase membrane staining in formalin fixed, paraffin-embedded human colon tissue. -SCBT QC
Date published: 2015-03-08
Rated 5 out of 5 by from Published flow cytometry data using tumour cellPublished flow cytometry data using tumour cell-derived microvesicles (TMV). -SCBT Publication Review
Date published: 2015-02-03
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EMMPRIN/CD147 抗体 (8D6) is rated 4.9 out of 5 by 9.
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