Date published: 2025-9-8

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eIF5A 抗体 (C-1): sc-390062

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说明书
  • eIF5A抗体(C-1)是小鼠单克隆IgG3 κ, 在1篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列9-124位于human物种的eIF5A1的N-terminus附近
  • 推荐用于 eIF5A1 and eIF5A2 of mouse, rat and human origin, and eIF5AL1 of human origin WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • m-IgG3 BP-HRP是eIF5A Antibody (C-1) 适用于 WB 应用。 的首选辅助检测试剂,该试剂现与eIF5A Antibody (C-1) 搭配使用(请参阅下面的订购信息)。

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在哺乳动物细胞中,翻译是在多肽链起始水平上由真核起始因子控制的。人类真核翻译起始因子5A基因,也被称为eIF-4D或eIF5A1,定位于染色体17p131,编码一个由154个氨基酸组成的蛋白质,该蛋白质与细胞多胺稳态有关。eIF5A1定位于哺乳动物细胞的核和细胞质区室,在那里它可以刺激核糖体肽基转移酶,并可能参与核质mRNA转运和/或蛋白质翻译。eIF5A1在Lys-50位置含有一个独特的由精胺衍生的翻译后修饰,即高哌嗪,这是eIF5A1生化活性和细胞增殖信号传导所必需的。此外,eIF5A1是人类免疫缺陷病毒1型(HIV-1)Rev反式激活蛋白功能的细胞辅因子。抑制eIF5A1与Rev的相互作用会阻断病毒复制周期。eIF5A2(真核翻译起始因子5A-2)是一种在所有生物体中都存在的高度保守的蛋白质,它是一个由153个氨基酸组成的蛋白质,与eIF5A1有94%的序列相似性,并且也共享高哌嗪残基。在卵巢癌中观察到编码eIF5A2的基因的扩增,并且eIF5A2的过度表达与卵巢癌的晚期有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

eIF5A 抗体 (C-1) 参考文献:

  1. eIF5A 在翻译延伸和终止子中发挥全球性功能  |  Schuller, AP., et al. 2017. Mol Cell. 66: 194-205.e5. PMID: 28392174
  2. 多胺和 eIF5A Hypusination 调节线粒体呼吸和巨噬细胞活化  |  Puleston, DJ., et al. 2019. Cell Metab. 30: 352-363.e8. PMID: 31130465
  3. 多胺能控制 eIF5A 下调, TFEB 翻译和自噬,从而逆转 B 细胞衰老。  |  Zhang, H., et al. 2019. Mol Cell. 76: 110-125.e9. PMID: 31474573
  4. eIF5A 在线粒体功能中的作用  |  Barba-Aliaga, M. and Alepuz, P. 2022. Int J Mol Sci. 23: PMID: 35163207
  5. YAP/TAZ通过多胺-eIF5A抑制-LSD1轴驱动细胞增殖和肿瘤生长。  |  Li, H., et al. 2022. Nat Cell Biol. 24: 373-383. PMID: 35177822
  6. 精氨酸介导的翻译因子 EIF5A 的减弱可改善线粒体脂肪酸氧化并防止非酒精性脂肪性肝炎的恶化。  |  Zhou, J., et al. 2022. Nat Commun. 13: 5202. PMID: 36057633
  7. 精氨酸代谢通过降低 eIF5A 的活性来调节人类红细胞的分化。  |  Gonzalez-Menendez, P., et al. 2023. Blood. 141: 2520-2536. PMID: 36735910
  8. 靶向抑制 eIF5Ahpu 可抑制口腔癌中肿瘤的生长和 M2 样肿瘤相关巨噬细胞的极化。  |  Zeng, J., et al. 2023. Cell Death Dis. 14: 579. PMID: 37653021
  9. hypusinated eIF5A的多面性:Hypusine回路的细胞环境特异性效应及对人类健康的影响。  |  Nakanishi, S. and Cleveland, JL. 2024. Int J Mol Sci. 25: PMID: 39125743
  10. 精氨酸-eIF5A轴是通过翻译控制激活肌肉干细胞的关键。  |  Zhang, Q., et al. 2024. Cell Discov. 10: 94. PMID: 39251577

订购信息

产品名称产品编号规格价格数量收藏夹

eIF5A 抗体 (C-1)

sc-390062
200 µg/ml
$316.00

eIF5A (C-1): m-IgG3 BP-HRP 套装

sc-550470
200 µg Ab; 40 µg BP
$354.00

Are there any issues with using sc-390062: eIF5A (C-1) mouse monoclonal primary antibody on mouse samples?

Asked by: jenniferc
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-390062 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Good antibody and nice servicethis antibody works well in my hand by western blot.
Date published: 2018-06-13
Rated 5 out of 5 by from Works very well in Western Blot with positiveWorks very well in Western Blot with positive detection in Jurkat and HeLa cells
Date published: 2014-11-03
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eIF5A 抗体 (C-1) is rated 5.0 out of 5 by 2.
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