ECSCR Antibody (A-6): sc-515896
- ECSCR Antibody (A-6) is a mouse monoclonal IgG1 κ ECSCR antibody provided at 200 µg/ml
- raised against amino acids 58-104 mapping within an internal region of ECSCR of human origin
- ECSCR Antibody (A-6) is recommended for detection of ECSCR of human origin by WB, IP, IF and ELISA
- Anti-ECSCR Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ECSCR Antibody (A-6) for WB applications. These reagents are now offered in bundles with ECSCR Antibody (A-6) (see ordering information below).
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ECSCR Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects ECSCR protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ECSCR antibody (A-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ECSCR, also known as endothelial cell-specific chemotaxis regulator, ARIA, or ECSM2, is a 205 amino acid single-pass type I membrane protein that plays a crucial role in endothelial cell function. Located primarily in endothelial cells and blood vessels, ECSCR is essential for regulating endothelial chemotaxis and tube formation, which are vital processes in angiogenesis and tissue repair. ECSCR interacts with Filamin 1, influencing cytoskeletal dynamics necessary for cell migration and shape changes. ECSCR modulates signaling pathways involved in cell survival and migration by suppressing tyrosine phosphorylation and reducing activity of the Shc-Ras-ERK pathway, thereby inhibiting epidermal growth factor receptor-mediated cell migration. This unique regulatory function positions ECSCR as a key player in both endothelial apoptosis and angiogenesis, with implications for various angiogenesis-related diseases. ECSCR′s evolutionary conservation underscores its importance in vascular biology and potential therapeutic targets in conditions characterized by abnormal angiogenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ECSCR Antibody (A-6) References:
- Subcutaneous abdominal preadipocyte differentiation in vitro inversely correlates with central obesity. | Permana, PA., et al. 2004. Am J Physiol Endocrinol Metab. 286: E958-62. PMID: 14970008
- [The filamin in cell signaling]. | Komaletdinova, FM. and Pinaev, GP. 2006. Tsitologiia. 48: 924-34. PMID: 17233478
- ECSM2, an endothelial specific filamin a binding protein that mediates chemotaxis. | Armstrong, LJ., et al. 2008. Arterioscler Thromb Vasc Biol. 28: 1640-6. PMID: 18556573
- Endothelial cell-specific molecule 2 (ECSM2) modulates actin remodeling and epidermal growth factor receptor signaling. | Ma, F., et al. 2009. Genes Cells. 14: 281-93. PMID: 19267780
- Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. | Ikeda, K., et al. 2009. Proc Natl Acad Sci U S A. 106: 8227-32. PMID: 19416853
- Functionally defining the endothelial transcriptome, from Robo4 to ECSCR. | Verissimo, AR., et al. 2009. Biochem Soc Trans. 37: 1214-7. PMID: 19909249
- Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity. | Verma, A., et al. 2010. Blood. 115: 4614-22. PMID: 20086248
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ECSCR Antibody (A-6) | sc-515896 | 200 µg/ml | $322.00 | |||
ECSCR Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-531552 | 200 µg Ab; 10 µg BP | $361.00 | |||
ECSCR Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-525273 | 200 µg Ab, 40 µg BP | $361.00 | |||
ECSCR Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-544618 | 200 µg Ab; 20 µg BP | $361.00 | |||
ECSCR Antibody (A-6) AC | sc-515896 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ECSCR Antibody (A-6) HRP | sc-515896 HRP | 200 µg/ml | $322.00 | |||
ECSCR Antibody (A-6) FITC | sc-515896 FITC | 200 µg/ml | $336.00 | |||
ECSCR Antibody (A-6) PE | sc-515896 PE | 200 µg/ml | $349.00 | |||
ECSCR Antibody (A-6) Alexa Fluor® 488 | sc-515896 AF488 | 200 µg/ml | $364.00 | |||
ECSCR Antibody (A-6) Alexa Fluor® 546 | sc-515896 AF546 | 200 µg/ml | $364.00 | |||
ECSCR Antibody (A-6) Alexa Fluor® 594 | sc-515896 AF594 | 200 µg/ml | $364.00 | |||
ECSCR Antibody (A-6) Alexa Fluor® 647 | sc-515896 AF647 | 200 µg/ml | $364.00 | |||
ECSCR Antibody (A-6) Alexa Fluor® 680 | sc-515896 AF680 | 200 µg/ml | $364.00 | |||
ECSCR Antibody (A-6) Alexa Fluor® 790 | sc-515896 AF790 | 200 µg/ml | $364.00 |