Date published: 2025-9-7

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Drebrin 抗体 (C-8): sc-374269

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说明书
  • Drebrin 抗体 C-8 是小鼠单克隆 IgG1 κ,Drebrin抗体, 在7篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Drebrin的N-terminus附近的氨基酸111-149之间
  • Drebrin 抗体 (C-8) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 Drebrin; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • 抗Drebrin抗体(C-8)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Drebrin (C-8): sc-374269免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP是Drebrin Antibody (C-8) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与Drebrin Antibody (C-8) 搭配使用(请参阅下面的订购信息)。

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関連項目

树突棘蛋白抗体(C-8)是一种IgG1 κ小鼠单克隆树突棘蛋白抗体(也称为DBN1抗体),可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类来源的树突棘蛋白。树突棘蛋白抗体(C-8)既有非偶联形式的抗树突棘蛋白抗体,也有多种偶联形式的抗树突棘蛋白抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。树突棘蛋白(发育调节脑蛋白)是胞质蛋白,可在大脑中结合F-肌动蛋白,并参与细胞迁移、神经元突起的延伸和树突的可塑性。树突棘蛋白有三种异构体:两种胚胎型(E1和E2)和一种成人型(A),它们都是由单个树突棘蛋白基因通过选择性RNA剪接产生的。树突棘蛋白主要在脑神经元中表达,但也存在于骨骼肌、心脏、胎盘、胰腺和肾脏中。树突棘蛋白已被指定为树突棘的标记物。大脑中树突棘蛋白水平的降低与阿尔茨海默病和唐氏综合征有关。编码人类树突棘蛋白的基因位于5号染色体上。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Drebrin 抗体 (C-8) 参考文献:

  1. 在培养的大脑皮层神经元中过量表达 drebrin 导致树突棘形状发生变化。  |  Hayashi, K. and Shirao, T. 1999. J Neurosci. 19: 3918-25. PMID: 10234022
  2. Drebrin 是一种广泛存在于交界斑块的肌动蛋白相关蛋白,它定义了极性上皮细胞中特定的微丝锚定系统。  |  Peitsch, WK., et al. 1999. Eur J Cell Biol. 78: 767-78. PMID: 10604653
  3. 在阿尔茨海默氏症和唐氏综合症患者的大脑中,树突棘蛋白 Drebrin 的含量成倍下降。  |  Shim, KS. and Lubec, G. 2002. Neurosci Lett. 324: 209-12. PMID: 12009525
  4. 在轴突侧枝的启动过程中,Drebrin 可协调肌动蛋白和微管细胞骨架。  |  Ketschek, A., et al. 2016. Dev Neurobiol. 76: 1092-110. PMID: 26731339
  5. 阿尔茨海默病中的 Drebrin  |  Ishizuka, Y. and Hanamura, K. 2017. Adv Exp Med Biol. 1006: 203-223. PMID: 28865022
  6. 难治性颞叶癫痫和海马硬化症患者的 Drebrin 表达模式。  |  Dombroski, TCD., et al. 2020. Epilepsia. 61: 1581-1594. PMID: 32662890
  7. Drebrin 通过与 CXCR4 相互作用调节迁移神经元的细胞骨架动态。  |  Shan, Y., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33414275
  8. Drebrin 通过限制平滑肌细胞的转分化减轻动脉粥样硬化。  |  Wu, JH., et al. 2022. Cardiovasc Res. 118: 772-784. PMID: 33914863
  9. Drebrin通过诱导整合素β1内吞促进肺腺癌细胞迁移。  |  Yu, Q., et al. 2022. Biochem Biophys Res Commun. 630: 175-182. PMID: 36155064
  10. 肌动蛋白结合蛋白drebrin会破坏NF2-LATS激酶复合物的组装,从而促进肝脏肿瘤发生。  |  Sun, Y., et al. 2024. Hepatology.. PMID: 39325963
  11. 微丝相关蛋白(drebrins)在脑形态发生中的作用:综述。  |  Shirao, T. 1995. J Biochem. 117: 231-6. PMID: 7608104
  12. drebrin对大鼠大脑皮层树突棘内细胞骨架的调节作用  |  Hayashi, K., et al. 1996. J Neurosci. 16: 7161-70. PMID: 8929425

订购信息

产品名称产品编号规格价格数量收藏夹

Drebrin 抗体 (C-8)

sc-374269
200 µg/ml
$316.00

Drebrin (C-8): m-IgG Fc BP-HRP 套装

sc-552024
200 µg Ab; 10 µg BP
$354.00

Drebrin 抗体 (C-8) AC

sc-374269 AC
500 µg/ml, 25% agarose
$416.00

Drebrin 抗体 (C-8) HRP

sc-374269 HRP
200 µg/ml
$316.00

Drebrin 抗体 (C-8) FITC

sc-374269 FITC
200 µg/ml
$330.00

Drebrin 抗体 (C-8) PE

sc-374269 PE
200 µg/ml
$343.00

Drebrin 抗体 (C-8) Alexa Fluor® 488

sc-374269 AF488
200 µg/ml
$357.00

Drebrin 抗体 (C-8) Alexa Fluor® 546

sc-374269 AF546
200 µg/ml
$357.00

Drebrin 抗体 (C-8) Alexa Fluor® 594

sc-374269 AF594
200 µg/ml
$357.00

Drebrin 抗体 (C-8) Alexa Fluor® 647

sc-374269 AF647
200 µg/ml
$357.00

Drebrin 抗体 (C-8) Alexa Fluor® 680

sc-374269 AF680
200 µg/ml
$357.00

Drebrin 抗体 (C-8) Alexa Fluor® 790

sc-374269 AF790
200 µg/ml
$357.00

Drebrin (C-8) 中和勝肽

sc-374269 P
100 µg/0.5 ml
$68.00

What is the host species for this product?

Asked by: Lorrie
Thank you for your question. The host species is mouse
Answered by: Tech Service 1
Date published: 2021-02-02

What application is the blocking peptide sc-374269 P appropriate for?

Asked by: Professor Griffin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Worked well for ICC of neurons.It stained our cell cultured neurons nicely at the recommended dilution, we were able to see the dendritic spines.
Date published: 2017-10-17
Rated 4 out of 5 by from Good Western Blot data of DrebrinClear Western Blot bands detection of estimated Drebrin in whole cell lysates of non-transfected human liver cancer cell line BEL-7404.
Date published: 2017-10-11
Rated 5 out of 5 by from Worked well for ICC of neurons.The trial of this antibody worked well for us at the given dilution of 1:200. We saw what was expected out of the ICC on cultured neurons.
Date published: 2017-09-26
Rated 5 out of 5 by from 功能很棒我们申请并收到了此抗体小样,用于WB实验,1:100的稀释此抗体,实验结果很好,扫膜后条带很特异,很清晰。
Date published: 2017-09-18
Rated 5 out of 5 by from very reliable AbThis is a very reliable Ab reagent with an excellent signal: ratio. It gives identical localisation
Date published: 2017-02-13
Rated 5 out of 5 by from Produced exceptional immunoperoxidase cytoplasmicProduced exceptional immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human heart muscle tissue. -SCBT QC
Date published: 2015-02-17
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Drebrin 抗体 (C-8) is rated 4.7 out of 5 by 7.
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