Diphtheria Toxin A Antibody (8A4): sc-51870

Diphtheria Toxin A Antibody (8A4) is a mouse monoclonal IgG2a antibody that detects Diphtheria Toxin A from Corynebacterium diphtheriae by enzyme-linked immunosorbent assay (ELISA). Diphtheria Toxin A plays a critical role in the pathogenicity of C. diphtheriae, causing severe effects of diphtheria, including cell death in the upper respiratory tract and systemic complications. Diphtheria Toxin A functions by catalyzing the ADP-ribosylation and subsequent inactivation of elongation factor 2 (eEF-2), essential for protein synthesis in eukaryotic cells. This inhibition of protein synthesis leads to cell death and contributes to the clinical manifestations of the disease. Diphtheria Toxin A consists of a Y-shaped molecule with three distinct domains: a catalytic domain (fragment A), a transmembrane domain, and a receptor-binding domain (fragment B). The unique arrangement of these domains facilitates cellular entry and enhances immune response evasion, making anti-Diphtheria Toxin A antibody (8A4) a valuable tool for studying diphtheria mechanisms and developing potential therapeutic strategies.

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Diphtheria Toxin A Antibody (8A4) References:

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