Dicoumarol CAS: 66-76-2
MF: C19H12O6
MW: 336.29
An inhibitor of reductase.

Dicoumarol (CAS 66-76-2)

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备用名: Dicumarol; 3,3'-Methylenebis(4-hydroxycoumarin); Bishydroxycoumarin
应用; Dicoumarol is an inhibitor of reductase
CAS号码: 66-76-2
纯度: ≥98%
分子量: 336.29
分子式: C19H12O6
补充资料: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Dicoumarol is a reductase inhibitor possessing anticoagulant properties. Dicoumarol also aids in apoptosis induction via stimulation of SAPK-JNK and NF-κB pathway blocking. This has no effect on the phosphorylation of P38 or activation of AKT. Additionally, Dicoumarol has been shown to block brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells. Dicoumarol is an inhibitor of NQO1.


参考文献

1. Weigert, R., et al. 1997. J. Biol. Chem. 30: 14200-14207. PMID: 9162051
2. Morrow, C.S., et al. 1998. J. Biol. Chem. 273, 20114-201120. PMID: 9685354
3. Cross, J.V., et al. 1999. J. Biol. Chem. 274: 31150-31154. PMID: 10531305
4. Pink, J.J., et al. 2000. J. Biol. Chem. 275: 5416-5424. PMID: 10681517
5. Krause, D., et al. 2001. J. Biol. Chem. 276: 19244-19252. PMID: 11278392
6. Seanor, K.L., et al. 2003. Antioxid. Redox. Signal. 5:103-113. PMID: 12626122

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in aqueous alkaline solutions, organic bases, 0.1 N NaOH (15 mg/ml), Pyridine (50 mg/ml), chloroform (slightly soluble), and benzene (slightly soluble). Insoluble in water, and alcohols.
保存 :
Store at 4° C
熔点 :
290-292° C (lit.)
沸点 :
~620.70° C at 760 mmHg (Predicted)
密度 :
~1.6 g/cm3 (Predicted)
折射率 :
n20D 1.73
IC50 :
Brefeldin A-dependent mono-ADP-ribosylation : IC50 = 180 µM; Golgi disassembly: IC50 = 150 µM (living cells); Quinone reductase 1: IC50 = 2.6 nM (human); Subtilisin/kexin type 7: IC50 = 1300 nM (human); HCT-116 (Colon carcinoma cells): IC50 = 19000 nM (human)
Ki 数据 :
Escherichia coli HisG: Ki= 50 µM; ATP phosphoribosyltransferase: Ki= 60 µM (Mycobacterium tuberculosis)
pK值 :
pKa: 4.20
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
GN7875000
PubChem CID :
默克索引 :
14: 3090
MDL 号码 :
MFCD00006857
EC号码 :
200-632-9
SMILES :
C1=CC=C2C(=C1)C(=C(C(=O)O2)CC3=C(C4=CC=CC=C4OC3=O)O)O

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引用1 - 77

PMID: # 16785233  He, X. et al. 2006. J. Biol. Chem. 281: 23620-23631.

PMID: # 15802389  Roymans, D. et al. 2005. Drug Metab. Dispos. 33: 1004-1016.

PMID: # 15142038  Jiang, H. et al. 2004. Biochem. J. 382: 33-41.

PMID: # 12799773  Kizu, R. et al. 2003. Arch. Toxicol. 77: 335-343.

PMID: # 27681582  Sci Rep. 33980.

PMID: # 31751648  J Ethnopharmacol. 112409.

PMID: # 31919413  Cell Death Dis. 11: 2.

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