DDX36 Antibody (E-4): sc-398418

DDX36 Antibody (E-4) is a mouse monoclonal IgG2b antibody that detects DDX36 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DDX36, also known as DEAH box protein 36, is a crucial RNA helicase composed of 1,008 amino acids, primarily expressed in the testis, where DDX36 plays a significant role in sex development and spermatogenesis. DDX36 is essential for the degradation and deadenylation of mRNAs that contain the consensus AU-rich element (ARE) sequence in their 3′-untranslated region, which is vital for regulating gene expression and maintaining cellular homeostasis. DDX36 is characterized by a unique structure, which includes one helicase ATP-binding domain and one helicase C-terminal domain, allowing DDX36 to unwind RNA structures and facilitate various RNA processing events. Notably, three isoforms of DDX36 result from alternative splicing, which may contribute to functional diversity and regulatory mechanisms in different cellular contexts. Anti-DDX36 antibody (E-4) is an invaluable tool for researchers studying RNA metabolism and its implications in developmental biology and disease.

The preferred DDX36 antibody is DDX36 Antibody (B-6): sc-377485.