Date published: 2025-9-6
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DDR2 Antibody (3B11E4) - Immunohistochemistry - Image 284815
DDR2 抗体 (3B11E4): sc-81707. 福尔马林固定, 石蜡包埋的人外阴/肛门皮肤组织的免疫过氧化物酶染色显示表皮细胞的胞浆染色.
DDR2 Antibody (3B11E4) - Immunohistochemistry - Image 284815
DDR2 抗体 (3B11E4): sc-81707. 福尔马林固定, 石蜡包埋的人外阴/肛门皮肤组织的免疫过氧化物酶染色显示表皮细胞的胞浆染色.
DDR2 Antibody (3B11E4) - Western Blotting - Image 137452
DDR2 抗体 (3B11E4): sc-81707. 截短的人重组 DDR2 蛋白的 Western 印迹分析.
DDR2 抗体 (3B11E4): sc-81707. 福尔马林固定, 石蜡包埋的人外阴/肛门皮肤组织的免疫过氧化物酶染色显示表皮细胞的胞浆染色.

DDR2 抗体 (3B11E4): sc-81707

2.7(6)
寫評論提問

说明书
  • DDR2 抗体 3B11E4 是小鼠单克隆 IgG2a κ，DDR2抗体, 在10篇文献中引用，规格为200 µg/ml
  • 与重组蛋白结合，该重组蛋白与DDR2的422-639的氨基酸对应，来源于human
  • DDR2 抗体 (3B11E4) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat 和human 来源的 DDR2
  • 抗DDR2抗体（3B11E4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取DDR2 (3B11E4): sc-81707的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRP 和 m-IgGκ BP-HRP 是 DDR2 抗体 (3B11E4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与DDR2 抗体 (3B11E4) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 DDR 抗体 包括 DDR2

DDR2抗体（3B11E4）是一种小鼠单克隆IgG2a kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学检测小鼠、大鼠和人类来源的DDR2蛋白。DDR2抗体（3B11E4）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。DDR2是盘蛋白域受体家族的一员，在调节细胞对胶原蛋白的反应中起着至关重要的作用，而胶原蛋白对于组织重塑和修复至关重要。DDR2主要位于细胞表面，与胶原纤维相互作用，触发影响细胞粘附、迁移和分化的信号通路。这种相互作用在伤口愈合和纤维化中尤为重要，因为DDR2的激活会导致基质金属蛋白酶-1的表达上调，而基质金属蛋白酶-1是一种降解细胞外基质成分的酶。了解DDR2的功能和信号传导机制对于阐明DDR2在包括癌症和纤维化疾病在内的各种病理条件中的作用至关重要，这使得抗DDR2抗体（3B11E4）成为研究人员研究这些过程的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

DDR2 抗体 (3B11E4) 参考文献:

  1. 生长因子与癌症  |  Aaronson, SA. 1991. Science. 254: 1146-53. PMID: 1659742
  2. 造血生长因子 KL 由 Sl 基因座编码，是 W 基因座的基因产物 c-kit 受体的配体。  |  Huang, E., et al. 1990. Cell. 63: 225-33. PMID: 1698557
  3. 无七膜配体新娘与无七酪氨酸激酶受体的相互作用。  |  Krämer, H., et al. 1991. Nature. 352: 207-12. PMID: 1857416
  4. 受体酪氨酸激酶：果蝇和小鼠发育过程中作用的遗传学证据。  |  Pawson, T. and Bernstein, A. 1990. Trends Genet. 6: 350-6. PMID: 1965067
  5. 具有酪氨酸激酶活性的受体的信号转导。  |  Ullrich, A. and Schlessinger, J. 1990. Cell. 61: 203-12. PMID: 2158859
  6. LncRNA CEBPA-DT通过与hnRNPC相互作用，激活DDR2/β-catenin，从而促进肝癌转移。  |  Cai, Y., et al. 2022. J Exp Clin Cancer Res. 41: 335. PMID: 36471363
  7. 基质DDR2通过调节代谢和分泌细胞外基质蛋白促进卵巢癌转移。  |  Schab, AM., et al. 2023. Mol Cancer Res. 21: 1234-1248. PMID: 37527178
  8. 探索骨形成、再生及其相关疾病中Discoidin域受体（DDR1和DDR2）的细胞和分子机制。  |  Mariadoss, AVA. and Wang, CZ. 2023. Int J Mol Sci. 24: PMID: 37834343
  9. DDR2调节的卵巢癌相关成纤维细胞中的精氨酸酶活性促进胶原蛋白的产生和肿瘤进展。  |  Akinjiyan, FA., et al. 2024. Oncogene. 43: 189-201. PMID: 37996700
  10. 受体酪氨酸激酶的鉴定和染色体图谱，该激酶的外结构域具有推定的磷脂结合序列。  |  Perez, JL., et al. 1994. Oncogene. 9: 211-9. PMID: 8302582
  11. 盘状蛋白结构域受体酪氨酸激酶被胶原蛋白激活。  |  Vogel, W., et al. 1997. Mol Cell. 1: 13-23. PMID: 9659899
  12. 孤儿受体酪氨酸激酶家族，其成员可作为非整合素胶原受体。  |  Shrivastava, A., et al. 1997. Mol Cell. 1: 25-34. PMID: 9659900

订购信息

产品名称产品编号规格价格数量收藏夹

DDR2 抗体 (3B11E4)

sc-81707
200 µg/ml
$316.00

DDR2 (3B11E4): m-IgG Fc BP-HRP 套装

sc-528711
200 µg Ab; 10 µg BP
$354.00

DDR2 (3B11E4): m-IgGκ BP-HRP 套装

sc-521179
200 µg Ab, 40 µg BP
$354.00

DDR2 (3B11E4): m-IgG2a BP-HRP 套装

sc-547153
200 µg Ab; 10 µg BP
$354.00

DDR2 抗体 (3B11E4) AC

sc-81707 AC
500 µg/ml, 25% agarose
$416.00

DDR2 抗体 (3B11E4) HRP

sc-81707 HRP
200 µg/ml
$316.00

DDR2 抗体 (3B11E4) FITC

sc-81707 FITC
200 µg/ml
$330.00

DDR2 抗体 (3B11E4) PE

sc-81707 PE
200 µg/ml
$343.00

DDR2 抗体 (3B11E4) Alexa Fluor® 488

sc-81707 AF488
200 µg/ml
$357.00

DDR2 抗体 (3B11E4) Alexa Fluor® 546

sc-81707 AF546
200 µg/ml
$357.00

DDR2 抗体 (3B11E4) Alexa Fluor® 594

sc-81707 AF594
200 µg/ml
$357.00

DDR2 抗体 (3B11E4) Alexa Fluor® 647

sc-81707 AF647
200 µg/ml
$357.00

DDR2 抗体 (3B11E4) Alexa Fluor® 680

sc-81707 AF680
200 µg/ml
$357.00

DDR2 抗体 (3B11E4) Alexa Fluor® 790

sc-81707 AF790
200 µg/ml
$357.00

what the the antigen retrieval used for Anti-DDR2 Antibody{3B11E4}

Asked by: Abdalla 55
Thank you for your question. We recommend sodium citrate with heat at pH 6. Please find the protocol for our antigen retrieval methods below. https://www.scbt.com/resources/protocols/immunoperoxidase-staining
Answered by: Santa Cruz TS
Date published: 2021-07-10

Hello. I would like to know whether this antibody binds the external region of the DDR2 cell receptor, or rather its internal region, as DDR2 is a transmembrane receptor. This detail is very important to us. Thank you in advance,

Asked by: hadasp
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Dallas Tech Service
Date published: 2021-04-07

Is it concenterated or diluted ? and if it diluted ! I need to know the dilution plz ! 

Asked by: rana
Thank you for your question. The antibody is provided in 1.0 ml PBS with sodium azide and gelatin at a concentration of 200 µg/ml.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-29

Can DDR2 (3B11E4): sc-81707 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: jerojero
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, DDR2 (3B11E4): sc-81707 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 1 out of 5 by from DDR2-AF546 for IF for mouse heartI purchased DDR2-AF546 and tried it for direct IF for mouse heart. There was no specific staining at 1:100, 1:50, 1:25, 1:10 and 1:5 dilution. Antibody from other company was used as a positive control.
Date published: 2019-12-18
Rated 3 out of 5 by from Weak nuclear stain by IF in lung cancer and CAFsStaining pattern by IF was weak, and showed nuclear localization and no plasma membrane localization.
Date published: 2019-06-26
Rated 3 out of 5 by from Stain works for IHC-PI tried the stain and did get some positive stains, but there was a little bit of background.
Date published: 2017-09-22
Rated 3 out of 5 by from So-soI used this antibody for immunofluorescent staining of mouse heart. Although there was moderate backgorund signal due to mouse on mouse staining, positive signal was detected compared to mouse IgG sample. sample: cryosection of mouse heart(pre-fix). blocking: M.O.M. kit (other vendor). primary ab: 1/50, 4 degree O/N. 2nd ab: anti-Mouse Alexa 594 or 633.
Date published: 2017-09-01
Rated 2 out of 5 by from Single strong band in the recombinant DDR2 proteinSingle strong band in the recombinant DDR2 protein. -SCBT QC
Date published: 2015-01-17
Rated 4 out of 5 by from Acceptable immunoperoxidase cytoplasmic stainingAcceptable immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human vulva/anal skin tissue. -SCBT QC
Date published: 2013-10-06
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DDR2 抗体 (3B11E4) is rated 2.7 out of 5 by 6.
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