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DCC 抗体 (A-1): sc-515834

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说明书
  • DCC 抗体 A-1 是小鼠单克隆 IgG1 κ,DCC抗体, 在4篇文献中引用,规格为200 µg/ml
  • 免疫human来源DCC近C-terminus的1159-1363氨基酸
  • DCC 抗体 (A-1) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 DCC
  • 抗DCC抗体(A-1)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取DCC (A-1): sc-515834免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是DCC Antibody (A-1) for WB applications. 的首选辅助检测试剂,这些试剂现与DCC Antibody (A-1) 打包提供(请参阅下面的订购信息)。

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関連項目

DCC抗体(A-1)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的DCC蛋白。DCC抗体(A-1)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。DCC蛋白(或称"结直肠癌缺失蛋白")是一种重要的跨膜蛋白,由1447个氨基酸组成,主要在发育中的大脑和神经管中表达,在神经系统发育过程中,DCC在调节定向迁移方面发挥着重要作用。DCC蛋白与Netrin-1(脊髓中神经轴突的关键趋化因子)相互作用,凸显了DCC在引导神经元生长和建立适当神经连接方面的重要性。DCC表达缺失与多种癌症有关,包括结肠直肠癌、乳腺癌、子宫内膜癌、脑癌、胰腺癌、前列腺癌以及白血病和神经母细胞瘤,这凸显了DCC作为肿瘤抑制剂的潜在作用。在研究中使用抗DCC抗体(A-1)有助于探索DCC在发育生物学和癌症研究中的复杂机制,为DCC在健康和疾病中的功能和意义提供宝贵的见解。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

DCC 参考文献:

  1. 依赖性受体 DCC 在结直肠癌发病机制中的作用。  |  Mehlen, P. and Fearon, ER. 2004. J Clin Oncol. 22: 3420-8. PMID: 15310786
  2. 网织蛋白-1 和依赖性受体 DCC 在癌细胞侵袭, 肿瘤生长和转移中的相反作用。  |  Rodrigues, S., et al. 2007. Oncogene. 26: 5615-25. PMID: 17334389
  3. 鉴定结直肠癌中发生改变的 18q 染色体基因。  |  Fearon, ER., et al. 1990. Science. 247: 49-56. PMID: 2294591
  4. 结直肠癌的等位基因型。  |  Vogelstein, B., et al. 1989. Science. 244: 207-11. PMID: 2565047
  5. 严重脑外伤中大肠癌(DCC)受体和血清 Netrin-1 的预后价值。  |  Zhang, Y., et al. 2022. J Clin Med. 11: PMID: 35806983
  6. 细胞分化和结直肠肿瘤发生过程中的 DCC 基因产物。  |  Hedrick, L., et al. 1994. Genes Dev. 8: 1174-83. PMID: 7926722
  7. 大肠癌(DCC)基因在正常组织和恶性组织中的表达和替代剪接。  |  Reale, MA., et al. 1994. Cancer Res. 54: 4493-501. PMID: 8044801
  8. 克隆大肠癌基因缺失的小鼠同源物(mDCC)及其在发育中的小鼠胚胎中的表达。  |  Cooper, HM., et al. 1995. Oncogene. 11: 2243-54. PMID: 8570174
  9. 血液恶性肿瘤中的 DCC(在结直肠癌中删除)失活。  |  Porfiri, E. 1995. Leuk Lymphoma. 18: 69-72. PMID: 8580831
  10. 造血细胞群中 DCC 蛋白的表达及其与白血病发生的关系。  |  Inokuchi, K., et al. 1996. J Clin Invest. 97: 852-7. PMID: 8609244
  11. 大肠癌中删除的基因(DCC)编码一种网状蛋白受体。  |  Keino-Masu, K., et al. 1996. Cell. 87: 175-85. PMID: 8861902
  12. DCC 表达缺失与胶质瘤进展  |  Reyes-Mugica, M., et al. 1997. Cancer Res. 57: 382-6. PMID: 9012460

订购信息

产品名称产品编号规格价格数量收藏夹

DCC 抗体 (A-1)

sc-515834
200 µg/ml
$316.00

DCC (A-1): m-IgG Fc BP-HRP 套装

sc-528064
200 µg Ab; 10 µg BP
$354.00

DCC (A-1): m-IgG1 BP-HRP 套装

sc-533437
200 µg Ab; 20 µg BP
$354.00

DCC 抗体 (A-1) AC

sc-515834 AC
500 µg/ml, 25% agarose
$416.00

DCC 抗体 (A-1) HRP

sc-515834 HRP
200 µg/ml
$316.00

DCC 抗体 (A-1) FITC

sc-515834 FITC
200 µg/ml
$330.00

DCC 抗体 (A-1) PE

sc-515834 PE
200 µg/ml
$343.00

DCC 抗体 (A-1) Alexa Fluor® 488

sc-515834 AF488
200 µg/ml
$357.00

DCC 抗体 (A-1) Alexa Fluor® 546

sc-515834 AF546
200 µg/ml
$357.00

DCC 抗体 (A-1) Alexa Fluor® 594

sc-515834 AF594
200 µg/ml
$357.00

DCC 抗体 (A-1) Alexa Fluor® 647

sc-515834 AF647
200 µg/ml
$357.00

DCC 抗体 (A-1) Alexa Fluor® 680

sc-515834 AF680
200 µg/ml
$357.00

DCC 抗体 (A-1) Alexa Fluor® 790

sc-515834 AF790
200 µg/ml
$357.00

Hello, Can I use this antibody to block DCC ligand binding sites in vitro?

Asked by: lple
Thank you for your question. This antibody has not been tested or published for any functional or blocking application so we do not know if it would work in that application.
Answered by: Technical Support
Date published: 2019-02-01

How much sample do you recommend loading on the gel for Western blot detection using DCC (A-1): sc-515834?

Asked by: Trav11
We recommend loading 40–60 µg whole cell lysate, 10–20 µg nuclear extract, 5-10 µg transfected lysate, or 10–20 ng purified protein per lane. A link to our complete Western blotting protocol is provided here for your reference: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-01
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Rated 5 out of 5 by from Good for Western BlotAntibody works for Western blot with mouse substantia nigra extract in published research. -SCBT QC
Date published: 2023-09-14
Rated 3 out of 5 by from Not very strong in hela whole cell lysis1:1000 in hela whole cell lysis Signal is not very strong.
Date published: 2017-08-12
Rated 3 out of 5 by from That is okIt is ok. But, there are too many non specific bands. (Hela cells whole cell lysis)
Date published: 2017-07-28
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DCC 抗体 (A-1) is rated 3.7 out of 5 by 3.
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