Dabigatran Ethyl Ester (CAS 429658-95-7)
Alternate Names:
N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine Ethyl Ester Hydrochloride Salt
CAS Number:
429658-95-7
Molecular Weight:
499.56
Molecular Formula:
C27H29N7O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dabigatran ethyl ester is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase. It offers a stable anticoagulation effect, eliminating the requirement for regular laboratory monitoring. Unlike dabigatran itself, the ethyl ester version is designed for increased lipophilicity, which can facilitate its passage through lipid membranes. Dabigatran Ethyl Ester serves as a key starting material in the preparation of dabigatran through enzymatic or chemical hydrolysis processes, where the ethyl ester group is removed to yield the active moiety.
Dabigatran Ethyl Ester (CAS 429658-95-7) References
- Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2). | Michaelis, S., et al. 2012. J Med Chem. 55: 3934-44. PMID: 22494098
- Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender. | Shi, J., et al. 2016. Biochem Pharmacol. 119: 76-84. PMID: 27614009
- Pharmacogenomics of Novel Direct Oral Anticoagulants: Newly Identified Genes and Genetic Variants. | Kanuri, SH. and Kreutz, RP. 2019. J Pers Med. 9: PMID: 30658513
- Dabigatran Acylglucuronide, the Major Metabolite of Dabigatran, Shows a Weaker Anticoagulant Effect than Dabigatran. | Kim, JM., et al. 2022. Pharmaceutics. 14: PMID: 35213990
- Carboxylesterase-2 plays a critical role in dabigatran etexilate active metabolite formation. | Laizure, SC., et al. 2022. Drug Metab Pharmacokinet. 47: 100479. PMID: 36375226
- In silico drug screen reveals potential competitive MTHFR inhibitors for clinical repurposing. | Keske, N., et al. 2023. J Biomol Struct Dyn. 1-14. PMID: 36597898
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dabigatran Ethyl Ester, 5 mg | sc-500659 | 5 mg | $347.00 |