cylindromatosis 1 Antibody (E-4): sc-74434

Cylindromatosis 1 Antibody (E-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects cylindromatosis 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-cylindromatosis 1 antibody (E-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cylindromatosis 1, encoded by the CYLD gene located on chromosome 16q12.1, plays a crucial role in cellular signaling pathways by acting as a deubiquitinating enzyme, essential for regulating protein degradation and maintaining cellular homeostasis. This function helps prevent misfolded protein accumulation and modulates signaling molecule activity, influencing cell proliferation and apoptosis. CYLD gene mutations can lead to familial cylindromatosis, characterized by multiple benign skin tumors called cylindromas, which may become infected and cause significant disfigurement and discomfort. Cylindromatosis 1 expression occurs in various tissues, including brain, gonads, skeletal muscle, spleen, liver, heart, lung, and leukocytes, highlighting widespread biological functions. Somatic CYLD gene mutations have been implicated in tumor oncogenesis with cylindromatous features, making cylindromatosis 1 research vital for understanding cancer biology.

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cylindromatosis 1 Antibody (E-4) References:

1. CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus-Associated Head and Neck Cancers.  |  Cui, Z., et al. 2021. Mol Cancer Res. 19: 14-24. PMID: 32883697
2. TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.  |  Zhu, G., et al. 2021. Nat Cell Biol. 23: 978-991. PMID: 34497368
3. Genetic Testing in CYLD Cutaneous Syndrome: An Update.  |  Nagy, N., et al. 2021. Appl Clin Genet. 14: 427-444. PMID: 34744449
4. FOSL1 promotes proneural-to-mesenchymal transition of glioblastoma stem cells via UBC9/CYLD/NF-κB axis.  |  Chen, Z., et al. 2022. Mol Ther. 30: 2568-2583. PMID: 35351656
5. Novel role of macrophage TXNIP-mediated CYLD-NRF2-OASL1 axis in stress-induced liver inflammation and cell death.  |  Zhan, Y., et al. 2022. JHEP Rep. 4: 100532. PMID: 36035360
6. SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD.  |  Griewahn, L., et al. 2023. Cell Rep. 42: 111961. PMID: 36640323
7. MALT1-dependent cleavage of CYLD promotes NF-κB signaling and growth of aggressive B-cell receptor-dependent lymphomas.  |  Minderman, M., et al. 2023. Blood Cancer J. 13: 37. PMID: 36922488
8. CYLD in health and disease.  |  Marín-Rubio, JL., et al. 2023. Dis Model Mech. 16: PMID: 37387450
9. CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression.  |  Gu, Y., et al. 2024. Cell Death Dis. 15: 79. PMID: 38246916
10. CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma.  |  Li, Y., et al. 2024. Cell Death Dis. 15: 95. PMID: 38287022

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cylindromatosis 1 Antibody (E-4) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-cylindromatosis 1 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cylindromatosis 1 Antibody (E-4) Specifications

Alternate Product Name: CYLD

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 537-956

Epitope Target: cylindromatosis 1

Epitope Species: human

Product Reactivity/Detection: cylindromatosis 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for cylindromatosis 1 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred cylindromatosis 1 antibody is cylindromatosis 1 Antibody (E-10): sc-74435.