Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

CUL-3 抗体 (G-8): sc-166110

4.6(10)
寫評論提問

说明书
  • CUL-3 抗体 G-8 是小鼠单克隆 IgG2b κ,CUL-3抗体, 在10篇文献中引用,规格为200 µg/ml
  • 免疫human物种的CUL-3 (cullin-3)的氨基酸1-293
  • CUL-3 抗体 (G-8) 推荐用于WB, IP, IF, IHC(P) 和 ELISA ,检测 mouse, rat, human 和 来源的CUL-3; 也和以下物种反应,包括: bovine and avian
  • 抗CUL-3抗体(G-8)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CUL-3 (G-8): sc-166110免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG2b BP-HRPm-IgGκ BP-HRP 是 CUL-3 抗体 (G-8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与CUL-3 抗体 (G-8) 组合成套装提供。 (请参阅下面的订购信息)。

快捷链接

関連項目

CUL-3抗体(G-8)是一种IgG2b κ小鼠单克隆CUL-3抗体(也称为Cullin 3抗体或CUL3抗体),可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源的CUL-3蛋白。CUL-3抗体(G-8)有非偶联的抗CUL-3抗体形式,以及多种偶联形式的抗CUL-3抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Cullin蛋白包含一个独特的介导因子家族,参与泛素(Ub)介导的蛋白质选择性靶向降解。CUL-1是酵母Cdc53的哺乳动物同源物,是E3泛素连接酶复合物SCF的组成部分。SCF(Skp1/CUL-1/F-box蛋白复合物)由Skp1与CUL-1和F-box蛋白(如Skp2)结合组成,决定复合物的底物特异性。CUL-1介导的泛素化导致细胞周期蛋白D、p21和细胞周期蛋白E的降解。另一个Cullin蛋白CUL-3促进细胞周期蛋白E的降解,而不依赖于SCF活性,而CUL-2与肿瘤抑制蛋白VHL和elongin B结合形成VBC复合物,其结构类似于SCF连接酶。蛋白质降解还通过CUL-4与Nedd-8结合进行,Nedd-8是一种泛素样蛋白,它在多功能E3复合物中起着活性成分的作用。CUL-5也被称为加压素激活的钙动员蛋白(VACM-1),因其与CUL-1具有大量的序列同源性,也属于Cullin家族。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CUL-3 抗体 (G-8) 参考文献:

  1. 一环定江山的 E3 泛素连接酶超家族。  |  Tyers, M. and Willems, AR. 1999. Science. 284: 601, 603-4. PMID: 10328744
  2. Cullin-3靶向泛素化细胞周期蛋白E,控制哺乳动物细胞的S期。  |  Singer, JD., et al. 1999. Genes Dev. 13: 2375-87. PMID: 10500095
  3. 鉴定作为活性 E3 泛素连接酶复合物一部分的 von Hippel-lindau 肿瘤抑制蛋白。  |  Iwai, K., et al. 1999. Proc Natl Acad Sci U S A. 96: 12436-41. PMID: 10535940
  4. cul-3b--一种新型人科动物 CUL-3 转录本变体的鉴定和特征描述。  |  Lu, L., et al. 2005. Asian J Androl. 7: 205-11. PMID: 15897978
  5. BTB蛋白MEL-26通过一种不依赖于CUL-3的机制促进秀丽隐杆线虫的细胞分裂。  |  Luke-Glaser, S., et al. 2005. Curr Biol. 15: 1605-15. PMID: 16169482
  6. CUL3系统在血管内皮细胞功能和血管生成中发挥不同作用的前景。  |  Sakaue, T., et al. 2017. J Biochem. 162: 237-245. PMID: 28981750
  7. 结构和生化表征有助于深入了解KEAP1-CUL3复合物的组装。  |  Adamson, RJ., et al. 2023. Free Radic Biol Med. 204: 215-225. PMID: 37156295
  8. CUL3通过MRPL12泛素化诱导肾小管上皮细胞线粒体功能障碍。  |  Ji, X., et al. 2023. FEBS J. 290: 5340-5352. PMID: 37526061
  9. cul-1是秀丽隐杆线虫细胞周期退出的必要条件,并确定了一个新的基因家族。  |  Kipreos, ET., et al. 1996. Cell. 85: 829-39. PMID: 8681378
  10. 位于染色体 11q22-23 上的 Cullin 基因家族成员人类 VACM-1 的鉴定和表达分析。  |  Byrd, PJ., et al. 1997. Genome Res. 7: 71-5. PMID: 9037604
  11. 在原发性乳腺癌中,草履虫 cul-4 基因的人类同源物被扩增和过表达。  |  Chen, LC., et al. 1998. Cancer Res. 58: 3677-83. PMID: 9721878
  12. 人类 CUL-1 与 SKP1/SKP2 复合物结合,并调节 p21(CIP1/WAF1)和细胞周期蛋白 D 蛋白。  |  Yu, ZK., et al. 1998. Proc Natl Acad Sci U S A. 95: 11324-9. PMID: 9736735

订购信息

产品名称产品编号规格价格数量收藏夹

CUL-3 抗体 (G-8)

sc-166110
200 µg/ml
$316.00

CUL-3 (G-8): m-IgGκ BP-HRP 套装

sc-521510
200 µg Ab, 40 µg BP
$354.00

CUL-3 (G-8): m-IgG2b BP-HRP 套装

sc-548917
200 µg Ab; 10 µg BP
$354.00

CUL-3 抗体 (G-8) AC

sc-166110 AC
500 µg/ml, 25% agarose
$416.00

CUL-3 抗体 (G-8) HRP

sc-166110 HRP
200 µg/ml
$316.00

CUL-3 抗体 (G-8) FITC

sc-166110 FITC
200 µg/ml
$330.00

CUL-3 抗体 (G-8) PE

sc-166110 PE
200 µg/ml
$343.00

CUL-3 抗体 (G-8) Alexa Fluor® 488

sc-166110 AF488
200 µg/ml
$357.00

CUL-3 抗体 (G-8) Alexa Fluor® 546

sc-166110 AF546
200 µg/ml
$357.00

CUL-3 抗体 (G-8) Alexa Fluor® 594

sc-166110 AF594
200 µg/ml
$357.00

CUL-3 抗体 (G-8) Alexa Fluor® 647

sc-166110 AF647
200 µg/ml
$357.00

CUL-3 抗体 (G-8) Alexa Fluor® 680

sc-166110 AF680
200 µg/ml
$357.00

CUL-3 抗体 (G-8) Alexa Fluor® 790

sc-166110 AF790
200 µg/ml
$357.00

I am using CUL-3 (G-8): sc-166110 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: TinTin
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
  • y_2025, m_8, d_28, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_166110, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 97ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by from Nice WBNice Western Blot data of VPS4A expression in HeLa whole cell lysate (25 μg protein lysate; ab dilution 1:1000; incubation at 4°C overnight)
Date published: 2021-07-23
Rated 4 out of 5 by from Works good in kidney homogenatesWe have bought this antibody for analyzing cullins in kidney homogenates using western blot. A specific band between 75-100 kDa was observed. Concentration 1:250 in BSA.
Date published: 2019-11-22
Rated 4 out of 5 by from works well in WBthe strongest band is the right size for Cul3, but there are some weak non specific bands and signal to noise could be better.
Date published: 2018-05-17
Rated 5 out of 5 by from Good antibodyThis antibody works well without any nonspecific background in western blotting experiments of hepatocarcinoma HepG2 cell line
Date published: 2017-05-12
Rated 5 out of 5 by from Excellent productThe CUL-3 Antibody (G-8): sc-166110 works very well for Western blot, showing strong band with minimal background.
Date published: 2017-02-03
Rated 5 out of 5 by from 效果不错~大概半个月前申请的cul-3抗体小样,最近做了western blot,可以检测到目的条带,效果还不错~!!!
Date published: 2017-01-09
Rated 4 out of 5 by from good in westernwork well in western in Jurkat cells, week in IP in Jurkat
Date published: 2016-11-14
Rated 5 out of 5 by from Robust signal in WB in human transfectedRobust signal in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-05-17
  • y_2025, m_8, d_28, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_10
  • loc_zh_CN, sid_166110, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT
CUL-3抗体 (G-8) is rated 4.6 out of 5 by 10.
  • y_2025, m_8, d_28, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_10
  • loc_zh_CN, sid_166110, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 106ms
  • REVIEWS, PRODUCT