Date published: 2025-9-9
访问圣克鲁斯动物健康

021-6093-6350

SCBT Portrait Logo
Seach Input
联系我们
登陆账户
快速订购
购物车 (0)
Csk Antibody (CSK-04) - Western Blotting - Image 12835
Csk 抗体 (CSK-04): sc-51580. BC3H1 全细胞裂解液中 Csk 表达的 Western 印迹分析.
Csk 抗体 (CSK-04): sc-51580. BC3H1 全细胞裂解液中 Csk 表达的 Western 印迹分析.

Csk 抗体 (CSK-04): sc-51580

4.0(5)
寫評論提問

说明书
  • Csk 抗体 CSK-04 是小鼠单克隆 IgG1, 在1篇文献中引用，提供 100 µl
  • 针对细菌表达的重组片段，对应于human Csk的氨基酸330-450
  • 推荐用于 mouse, rat 和 human 来源的Csk WB 和 IP检测
  • 目前，我们还没有完成Csk 抗体 (CSK-04)的首选二抗检测试剂的鉴定。这项工作正在进行中。

快捷链接

相关产品
描述
基因信息
说明书与实验方案
研究信息

関連項目

所有Src基因家族酪氨酸激酶的成员都以羧基末端结构域的酪氨酸为特征，该酪氨酸在酶的非活性形式中高度磷酸化，而在酶活性时磷酸化程度则低得多。对于Src p60，Y527就是这种酪氨酸；然而，当Y527被苯丙氨酸取代时，c-Src的突变体发生转化，并显示出比其正常对应物高5-10倍的激酶活性。Csk已被鉴定为Src相关酪氨酸激酶，具有SH2和SH3结构域以及催化结构域，但缺少SH3结构域氨基末端以及羧基末端调节序列的序列。Csk在Y527上磷酸化Src，并通过羧基末端调节位点的酪氨酸磷酸化下调Lyn、Fyn和Lck。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Csk 抗体 (CSK-04) 参考文献:

  1. C-末端Src激酶（CSK）和CSK同源激酶（CHK）--Src家族蛋白激酶的内源性负调节因子。  |  Chong, YP., et al. 2005. Growth Factors. 23: 233-44. PMID: 16243715
  2. 调节CSK家族激酶的调节和催化作用及其对Src家族激酶的抑制作用的结构元素和变构机制。  |  Ia, KK., et al. 2010. Growth Factors. 28: 329-50. PMID: 20476842
  3. Csk调节血管紧张素II诱导的足细胞凋亡。  |  Zhang, L., et al. 2016. Apoptosis. 21: 846-55. PMID: 27225249
  4. SH3结构域突变选择性破坏Csk同源二聚体或PTPN22结合。  |  Brian, BF., et al. 2022. Sci Rep. 12: 5875. PMID: 35393453
  5. 酪氨酸蛋白激酶CSK的细胞凋亡调节。  |  Fortner, A., et al. 2022. Front Cell Dev Biol. 10: 1078180. PMID: 36578781
  6. Csk蛋白酪氨酸激酶催化与调节结构功能关系的剖析。  |  Sun, G. and Ayrapetov, MK. 2023. Front Cell Dev Biol. 11: 1148352. PMID: 36936693
  7. 调节、靶标和功能。  |  Zhu, S., et al. 2023. Front Cell Dev Biol. 11: 1206539. PMID: 37397251
  8. 癌症中整合素介导的CSK信号传导。  |  Maldonado, H. and Leyton, L. 2023. Front Cell Dev Biol. 11: 1214787. PMID: 37519303
  9. CSK可能是反映胃癌免疫状态的潜在预后生物标志物。  |  Yan, X. and Huan, J. 2024. Eur Rev Med Pharmacol Sci. 28: 221-230. PMID: 38235873
  10. Csk抑制BCR介导的ROS产生，有助于生发中心的选择和亲和力成熟。  |  Inoue, T., et al. 2024. J Exp Med. 221: PMID: 38753246

订购信息

产品名称产品编号规格价格数量收藏夹

Csk 抗体 (CSK-04)

sc-51580
100 µl
$316.00

What is the concentration of sc-51580: Csk (CSK-04) monoclonal antibody?

Asked by: cjMara
Thank you for your question. The concentration of Csk (CSK-04): sc-51580 has not been characterized. We provide 100 µl of this antibody
Answered by: Technical Support
Date published: 2017-03-24
  • y_2025, m_9, d_8, h_8CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_51580, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 110ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by from Strong positive band observed in WB in mouseStrong positive band observed in WB in mouse Csk transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-06-08
Rated 4 out of 5 by from Band of interest detected in WB in JurkatBand of interest detected in WB in Jurkat whole cell lysate. -SCBT QC
Date published: 2015-05-08
Rated 4 out of 5 by from No commentNo comment.
Date published: 2015-03-27
Rated 4 out of 5 by from Robust band observed in WB in human Csk transfectedRobust band observed in WB in human Csk transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-03-19
Rated 4 out of 5 by from Performs well in WesternPerforms well in Western, good signal with BC3H1 whole cell lysate. -SCBT QC
Date published: 2015-02-22
  • y_2025, m_9, d_8, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_5
  • loc_zh_CN, sid_51580, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 17ms
  • REVIEWS, PRODUCT
Csk 抗体 (CSK-04) is rated 4.0 out of 5 by 5.
  • y_2025, m_9, d_8, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_5
  • loc_zh_CN, sid_51580, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 105ms
  • REVIEWS, PRODUCT
021-6093-6350
访问 Santa Cruz Animal Health|访问 San Juan Ranch
Santa Cruz Biotechnology, Inc. 是生物医学研究市场产品开发的世界领导者。请拨打0086-021-60936350联系我们。
版权所有© 2007-2025 Santa Cruz Biotechnology, Inc. 保留所有权利。”Santa Cruz Biotechnology” 和Santa Cruz Biotechnology, Inc.的商标，”Santa Cruz Animal Health”, “San Juan Ranch”, “Supplement of Champions”, San Juan Ranch的商标，”UltraCruz”, “ChemCruz”, “ImmunoCruz”, “ExactaCruz”, 和 “EZ Touch”是Santa Cruz Biotechnology, Inc.的注册商标。所有商标均为其各自所有者的财产。