Date published: 2025-9-6

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CSB 抗体 (D-7): sc-166042

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说明书
  • CSB 抗体 D-7 是小鼠单克隆 IgG1 κ,CSB抗体, 在3篇文献中引用,规格为200 µg/ml
  • 免疫human物种的CSB的氨基酸1-300
  • CSB 抗体 (D-7) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 CSB
  • 抗CSB抗体(D-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CSB (D-7): sc-166042免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP 是 CSB 抗体 (D-7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与CSB 抗体 (D-7) 组合成套装提供。 (请参阅下面的订购信息)。其他m-IgGκ BP 偶联产品,请参阅我们的小鼠 IgG 结合蛋白完整列表。

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関連項目

CSB抗体(D-7)是一种IgG1 κ小鼠单克隆CSB抗体(也称为ERPG3抗体、ERCC切除修复6抗体、染色质重塑因子抗体、DNA切除修复蛋白ERCC-6抗体、Cockayne综合征蛋白CSB抗体、ATP依赖性解旋酶ERCC6抗体、ARMD5抗体、RAD26抗体、COFS1抗体、POF11抗体、UVSS1抗体、CKN2抗体或COFS抗体),可通过WB、IP、IF、IHC(P)和ELISA检测人源CSB蛋白。CSB抗体(D-7)既可以是非偶联的抗CSB抗体形式,也可以是多种偶联形式的抗CSB抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。DNA损伤的核苷酸切除修复在模板链(即转录链)上发生得更快且频率更高,而在编码链(即非转录链)或转录不活跃的DNA上发生的程度要小得多。CSA和CSB是两个相关基因,负责指导这种优先的DNA修复模式,称为转录修复偶联。来自紫外线敏感的核苷酸切除修复紊乱症Cockayne综合征(CS)患者的细胞具有影响这些基因的特定突变,并导致活化基因转录链上的优先修复缺陷。CSA是一种属于"WD-repeat"蛋白家族的蛋白质。CSB也被称为切除修复交叉互补蛋白-6(ERCC-6),是酵母Rad26蛋白的同源物。CSB属于SWI/SNF蛋白家族,因为它含有解旋酶基序和ATP酶活性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CSB 抗体 (D-7) 参考文献:

  1. ERCC6是推定螺旋酶亚家族的成员,参与了科克恩综合征和活性基因的优先修复。  |  Troelstra, C., et al. 1992. Cell. 71: 939-53. PMID: 1339317
  2. 科凯恩综合征 B 组(CSB)蛋白在碱基切除修复和衰老中的作用。  |  Stevnsner, T., et al. 2008. Mech Ageing Dev. 129: 441-8. PMID: 18541289
  3. CSB 与 SMARCAL1 合作,维持 ALT 细胞端粒的稳定性。  |  Feng, E., et al. 2020. J Cell Sci. 133: PMID: 31974116
  4. DNA 损伤修复后,CSB-PAF1C 轴可恢复过程性转录物延伸。  |  van den Heuvel, D., et al. 2021. Nat Commun. 12: 1342. PMID: 33637760
  5. CSB 蛋白在拓扑异构酶 2 抑制剂诱导的 DNA 病变中的功能  |  Busatto, FF., et al. 2021. Front Cell Dev Biol. 9: 727836. PMID: 34746125
  6. CSB 在喜树碱诱导的 DNA 复制压力下调控途径选择  |  Batenburg, NL., et al. 2023. Int J Mol Sci. 24: PMID: 37569794
  7. 科凯恩综合征 A 组基因编码一种 WD 重复蛋白,它与 CSB 蛋白和 RNA 聚合酶 II TFIIH 的一个亚基相互作用。  |  Henning, KA., et al. 1995. Cell. 82: 555-64. PMID: 7664335
  8. 切除修复基因 ERCC6 的结构和表达,它与人类 B 组科凯恩氏综合征疾病有关。  |  Troelstra, C., et al. 1993. Nucleic Acids Res. 21: 419-26. PMID: 8382798
  9. CSB/p38/RK 应激反应激酶在 LPS 和细胞因子信号机制中的作用  |  Lee, JC. and Young, PR. 1996. J Leukoc Biol. 59: 152-7. PMID: 8603987
  10. 涉及人类 RNA 聚合酶 II 转录/核苷酸切除修复复合体 TFIIH, 核苷酸切除修复蛋白 XPG 和 Cockayne 综合征 B 组(CSB)蛋白的相互作用。  |  Iyer, N., et al. 1996. Biochemistry. 35: 2157-67. PMID: 8652557
  11. 科凯综合征 B 蛋白参与转录耦合 DNA 修复,它位于含 RNA 聚合酶 II 的复合体中。  |  van Gool, AJ., et al. 1997. EMBO J. 16: 5955-65. PMID: 9312053
  12. 含有 Cockayne 综合征 B 组蛋白的 RNA 聚合酶 II 延长复合体与含有转录因子 IIH 成分 xeroderma pigmentosum B 和 p62 的分子复合体相互作用。  |  Tantin, D. 1998. J Biol Chem. 273: 27794-9. PMID: 9774388

订购信息

产品名称产品编号规格价格数量收藏夹

CSB 抗体 (D-7)

sc-166042
200 µg/ml
$316.00

CSB (D-7): m-IgGκ BP-HRP 套装

sc-521493
200 µg Ab, 40 µg BP
$354.00

CSB 抗体 (D-7) AC

sc-166042 AC
500 µg/ml, 25% agarose
$416.00

CSB 抗体 (D-7) HRP

sc-166042 HRP
200 µg/ml
$316.00

CSB 抗体 (D-7) FITC

sc-166042 FITC
200 µg/ml
$330.00

CSB 抗体 (D-7) PE

sc-166042 PE
200 µg/ml
$343.00

CSB 抗体 (D-7) Alexa Fluor® 488

sc-166042 AF488
200 µg/ml
$357.00

CSB 抗体 (D-7) Alexa Fluor® 546

sc-166042 AF546
200 µg/ml
$357.00

CSB 抗体 (D-7) Alexa Fluor® 594

sc-166042 AF594
200 µg/ml
$357.00

CSB 抗体 (D-7) Alexa Fluor® 647

sc-166042 AF647
200 µg/ml
$357.00

CSB 抗体 (D-7) Alexa Fluor® 680

sc-166042 AF680
200 µg/ml
$357.00

CSB 抗体 (D-7) Alexa Fluor® 790

sc-166042 AF790
200 µg/ml
$357.00

Does this antibody recognize mouse CSB?

Asked by: Sarah Shuck
Thank you for your question. We have not yet tested this antibody, CSB (D-7): sc-166042, for reactivity with mouse samples and so this species reactivity is not currently recommended at this time. For detection of CSB of mouse origin, we would recommend an alternative antibody, CSB (E-6): sc-398022, which has been tested for reactivity with mouse, rat and human samples. A link to that product information is provided below as a reference. https://www.scbt.com/scbt/product/csb-antibody-e-6
Answered by: Technical Support
Date published: 2017-09-11

I am using CSB (D-7): sc-166042 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: jenniferc
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from CSB antibodyCSB antibody well recognized the CSB protein in human cell extract
Date published: 2021-11-16
Rated 5 out of 5 by from Great antibodyGreat results with CSB Antibody (D-7) by Western blot and IHCP
Date published: 2017-02-01
Rated 5 out of 5 by from Produced excellent immunoperoxidase nuclearProduced excellent immunoperoxidase nuclear staining in formalin fixed, paraffin-embedded human oral mucosa tissue. -SCBT QC
Date published: 2015-05-20
Rated 5 out of 5 by from Nice Western Blot data of CSB expressionNice Western Blot data of CSB expression in HeLa and BJAB nuclear extracts. -SCBT QC
Date published: 2014-07-21
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CSB 抗体 (D-7) is rated 4.8 out of 5 by 4.
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