CRTAP Antibody (D-1): sc-376617

CRTAP Antibody (D-1) is a mouse monoclonal IgG1 antibody that detects CRTAP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CRTAP, also known as cartilage associated protein or leprecan-like 3, is a secreted protein primarily located in the extracellular space, where CRTAP plays a crucial role in collagen post-translational modifications, extracellular fibril assembly, and intracellular trafficking. CRTAP is predominantly expressed in articular chondrocytes and is essential for normal bone formation, as CRTAP contains a signal peptide and a tetratricopeptide-like helical domain. Within the endoplasmic reticulum, CRTAP forms a complex with Gros1 and cyclophilin B, which is vital for the efficient 3-hydroxylation of prolyl residues in Collagen Type I molecules, the major structural proteins of skin and bone. Mutations in the gene encoding CRTAP can lead to autosomal recessive osteogenesis imperfecta (OI) types 7 and 2B, conditions characterized by bone fragility and increased susceptibility to fractures. OI type 7 is a milder form of the disorder, while OI type 2B is associated with neonatal lethality, underscoring the importance of CRTAP in skeletal health and development. Anti-CRTAP antibody (D-1) is an invaluable tool for researchers studying the mechanisms of collagen synthesis and the implications of CRTAP in bone-related diseases.

The preferred CRTAP antibody is CRTAP Antibody (E-1): sc-393136.