Coumermycin A1 CAS: 4434-05-3
MF: C55H59N5O20
MW: 1110.08
An activator of JAK2 and Raf-1.

Coumermycin A1 (CAS 4434-05-3)

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同义词: Notomycin
应用; An activator of JAK2 and Raf-1
CAS号码: 4434-05-3
分子量: 1110.08
分子式: C55H59N5O20
* 参考分析证明 大量特定数据 (包括水 含量).
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Coumermycin A1, a cell permeable antibiotic, has been found to be a dimerizing agent that can activate a modified Raf-1 protein and stimulate the mitogen-activated protein kinase cascade. This compound has also been reported to induce autophosphorylation of GyrB-Janus Kinase (JAK) 2 fusion proteins, thus bypassing receptor activation. JAKs are cytoplasmic protein kinases that interact with intracellular domains of cytokine receptors which plays an important role in signal transduction. The activation of JAK is thought to induce cell proliferation. Studies suggest that Coumermycin A1 can inhibit the supercoiling activity of gyrase by binding to the gyrase B subunit.


参考文献

1. Farrar, M.A. and Alberol-Ila, R.M. 1996. Nature. 383: 178-181. PMID: 8774884
2. Tsai, F.T., et al. 1997. Proteins. 28: 41-52. PMID: 9144789
3. Mizuguchi, R. and Hatakeyama, M. 1998. J. Biol. Chem. 273: 32297-32303. PMID: 9822709
4. Mohi, M.G., et al. 1998. Mol. Biol. Cell. 9: 3299-3308. PMID: 9843570

物理状态 :
Solid
溶解度 :
Soluble in DMSO (50 mg/ml).
保存 :
Store at room temperature
折射率 :
n20D 1.68
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
UX9375000
PubChem CID :
54678496
MDL 号码 :
MFCD00057312
Beilstein 注册 :
470805
SMILES :
CC1=CC=C(N1)C(=O)OC2C(C(OC(C2OC)(C)C)OC3=C(C4=C(C=C3)C(=C(C(=O)O4)NC(=O)C5=CNC(=C5C)C(=O)NC6=C(C7=C(C(=C(C=C7)OC8C(C(C(C(O8)(C)C)OC)OC(=O)C9=CC=C(N9)C)O)C)OC6=O)O)O)C)O

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引用1 - 22

PMID: # 29885817  Bassa, BV. et al. 1999. Neuropharmacology. 277: F328-37.

PMID: # 30054044  Biochem. Biophys. Res. Commun. 503: 1747-1753.

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