Date published: 2025-9-5

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COQ6 抗体 (H-1): sc-393932

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说明书
  • COQ6 抗体 H-1 是小鼠单克隆 IgG1 κ,COQ6抗体, 在8篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的COQ6的内部区域内的氨基酸130-155之间
  • COQ6 抗体 (H-1) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 COQ6; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • 抗COQ6抗体(H-1)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取COQ6 (H-1): sc-393932免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是COQ6 Antibody (H-1) for WB applications. 的首选辅助检测试剂,这些试剂现与COQ6 Antibody (H-1) 打包提供(请参阅下面的订购信息)。

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関連項目

COQ6抗体(H-1)是一种IgG1 κ型小鼠单克隆COQ6抗体(也称为COQ6抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的COQ6蛋白。COQ6抗体(H-1)既有非偶联的抗COQ6抗体形式,也有多种偶联形式的抗COQ6抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。辅酶Q(CoQ),也称为泛醌,是电子传递链中的脂溶性组成部分,参与线粒体中的有氧细胞呼吸,对于ATP依赖的能量产生至关重要。CoQ由疏水的异戊烯尾部和醌头部组成,前者将其锚定在膜上,后者负责CoQ在呼吸链中的活性。CoQ的生物合成需要一个由COQ1到COQ10组成的多亚基酶复合物的形成,这在酵母中具有高度特征。特别是,COQ6编码一种黄素依赖性单加氧酶,该酶对酵母中辅酶Q的生物合成至关重要。在人类中,COQ6是一种由468个氨基酸组成的蛋白质,其功能尚未完全阐明。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

COQ6 抗体 (H-1) 参考文献:

  1. 酿酒酵母 COQ6 基因编码辅酶 Q 生物合成所需的线粒体黄素依赖性单氧化酶。  |  Gin, P., et al. 2003. J Biol Chem. 278: 25308-16. PMID: 12721307
  2. 一个 tRNA(TRP)基因介导了先前归因于 ABC1/COQ8 的 cbs2-223 抑制作用。  |  Hsieh, EJ., et al. 2004. Biochem Biophys Res Commun. 317: 648-53. PMID: 15063807
  3. 酿酒酵母 Coq9 多肽是线粒体辅酶 Q 生物合成复合物的一个亚基。  |  Hsieh, EJ., et al. 2007. Arch Biochem Biophys. 463: 19-26. PMID: 17391640
  4. 线粒体疾病  |  Zeviani, M. and Carelli, V. 2007. Curr Opin Neurol. 20: 564-71. PMID: 17885446
  5. 辅酶 Q9 在转化为辅酶 Q10 后可保护心脏。  |  Lekli, I., et al. 2008. J Agric Food Chem. 56: 5331-7. PMID: 18543930
  6. 酵母和其他生物对辅酶 Q10 的生物合成和生物生产。  |  Kawamukai, M. 2009. Biotechnol Appl Biochem. 53: 217-26. PMID: 19531029
  7. 人类患者的 COQ6 基因突变会导致肾病综合征和感音神经性耳聋。  |  Heeringa, SF., et al. 2011. J Clin Invest. 121: 2013-24. PMID: 21540551
  8. 辅酶 Q10 可在生殖衰老过程中恢复卵母细胞线粒体功能和生育能力。  |  Ben-Meir, A., et al. 2015. Aging Cell. 14: 887-95. PMID: 26111777
  9. [辅酶Q(10)治疗一名COQ6基因突变诱发的肾病综合征患儿及文献综述]。  |  Cao, Q., et al. 2017. Zhonghua Er Ke Za Zhi. 55: 135-138. PMID: 28173653
  10. 肾病综合征、感音神经性耳聋和视神经萎缩患者的 COQ6 基因突变。  |  Justine Perrin, R., et al. 2020. JIMD Rep. 54: 37-44. PMID: 32685349
  11. 一个家族因两种新型 COQ6 变异而出现致命的原发性辅酶 Q10 缺乏症。  |  Wang, N., et al. 2021. Front Genet. 12: 811833. PMID: 35111204
  12. COQ6 打破了免疫和新陈代谢的预期。  |  Weinberg, SE. and Chandel, NS. 2024. Nat Immunol. 25: 2170-2172. PMID: 39496955

订购信息

产品名称产品编号规格价格数量收藏夹

COQ6 抗体 (H-1)

sc-393932
200 µg/ml
$316.00

COQ6 (H-1): m-IgG Fc BP-HRP 套装

sc-527719
200 µg Ab; 10 µg BP
$354.00

COQ6 (H-1): m-IgG1 BP-HRP 套装

sc-533092
200 µg Ab; 20 µg BP
$354.00

COQ6 抗体 (H-1) AC

sc-393932 AC
500 µg/ml, 25% agarose
$416.00

COQ6 抗体 (H-1) HRP

sc-393932 HRP
200 µg/ml
$316.00

COQ6 抗体 (H-1) FITC

sc-393932 FITC
200 µg/ml
$330.00

COQ6 抗体 (H-1) PE

sc-393932 PE
200 µg/ml
$343.00

COQ6 抗体 (H-1) Alexa Fluor® 488

sc-393932 AF488
200 µg/ml
$357.00

COQ6 抗体 (H-1) Alexa Fluor® 546

sc-393932 AF546
200 µg/ml
$357.00

COQ6 抗体 (H-1) Alexa Fluor® 594

sc-393932 AF594
200 µg/ml
$357.00

COQ6 抗体 (H-1) Alexa Fluor® 647

sc-393932 AF647
200 µg/ml
$357.00

COQ6 抗体 (H-1) Alexa Fluor® 680

sc-393932 AF680
200 µg/ml
$357.00

COQ6 抗体 (H-1) Alexa Fluor® 790

sc-393932 AF790
200 µg/ml
$357.00

COQ6 (H-1) 中和勝肽

sc-393932 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-393932 P appropriate for?

Asked by: Germaine
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Excellent COQ6 antibody for Western blotSpecific protein signal bands without background noise were observed on the Western blot. We have used this antibody to detect COQ6 in human cells for two publications: (1) doi: 10.1016/j.bbabio.2020.148192; (2) doi: 10.1016/j.bbabio.2024.149492
Date published: 2024-08-16
Rated 5 out of 5 by from best CoQ6 for mouse samplesthis is the best CoQ6 antibody that works for mouse samples
Date published: 2017-09-29
Rated 5 out of 5 by from Very good Western blot data of COQ6 expressionVery good Western blot data of COQ6 expression in Hep G2, HCT-116, NCI-H460 and COLO 205 whole cell lysates and human heart and mouse brain tissue extracts. -SCBT QC
Date published: 2013-10-19
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COQ6 抗体 (H-1) is rated 5.0 out of 5 by 3.
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